Document Detail

Uterocalin: a mouse acute phase protein expressed in the uterus around birth.
MedLine Citation:
PMID:  9094098     Owner:  NLM     Status:  MEDLINE    
Mouse SIP24/24p3 is a 24 kDa lipocalin expressed in the liver and secreted into the bloodstream during the acute phase response (APR). In this report we show that SIP24/24p3 mRNA and protein are expressed in the uterus around parturition at levels higher than are found in the liver during the APR. Because of the unique expression of this lipocalin in the uterus, we have named this protein uterocalin. Contrary to its expression pattern during the APR, there is little or no expression of uterocalin in the liver during or after pregnancy. Also, unlike the APR, and despite its high level of expression in the uterus, uterocalin was not detected in the blood or amniotic fluid. Day 19 and postpartum uterine samples were examined by immunocytochemistry. Uterocalin was found in the luminal epithelium at day 19 and in the glandular epithelium in postpartum samples. Although some uterocalin remained in the luminal epithelium, most of the uterocalin was found deposited on its luminal surface. The uterus undergoes extensive tissue remodeling during pregnancy and suffers stress and tissue damage around parturition. Uterocalin could be part of the local inflammatory response associated with parturition.
Q Liu; J Ryon; M Nilsen-Hamilton
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Molecular reproduction and development     Volume:  46     ISSN:  1040-452X     ISO Abbreviation:  Mol. Reprod. Dev.     Publication Date:  1997 Apr 
Date Detail:
Created Date:  1997-06-10     Completed Date:  1997-06-10     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8903333     Medline TA:  Mol Reprod Dev     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  507-14     Citation Subset:  IM    
Department of Biochemistry and Biophysics, Iowa State University, Ames 50011, USA.
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MeSH Terms
Acute-Phase Proteins / biosynthesis*
Amniotic Fluid / metabolism
Blotting, Northern
Blotting, Western
Epithelium / metabolism
Gene Expression Regulation, Developmental
Labor, Obstetric / physiology*
Liver / metabolism
Oncogene Proteins / biosynthesis*
RNA, Messenger / biosynthesis
Uterus / metabolism*
Reg. No./Substance:
0/Acute-Phase Proteins; 0/Lipocalins; 0/Oncogene Proteins; 0/RNA, Messenger; 126469-30-5/Lcn2 protein, mouse

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