Document Detail

Uterocalin: a mouse acute phase protein expressed in the uterus around birth.
MedLine Citation:
PMID:  9094098     Owner:  NLM     Status:  MEDLINE    
Mouse SIP24/24p3 is a 24 kDa lipocalin expressed in the liver and secreted into the bloodstream during the acute phase response (APR). In this report we show that SIP24/24p3 mRNA and protein are expressed in the uterus around parturition at levels higher than are found in the liver during the APR. Because of the unique expression of this lipocalin in the uterus, we have named this protein uterocalin. Contrary to its expression pattern during the APR, there is little or no expression of uterocalin in the liver during or after pregnancy. Also, unlike the APR, and despite its high level of expression in the uterus, uterocalin was not detected in the blood or amniotic fluid. Day 19 and postpartum uterine samples were examined by immunocytochemistry. Uterocalin was found in the luminal epithelium at day 19 and in the glandular epithelium in postpartum samples. Although some uterocalin remained in the luminal epithelium, most of the uterocalin was found deposited on its luminal surface. The uterus undergoes extensive tissue remodeling during pregnancy and suffers stress and tissue damage around parturition. Uterocalin could be part of the local inflammatory response associated with parturition.
Q Liu; J Ryon; M Nilsen-Hamilton
Related Documents :
25448508 - Expectant management of mild preeclampsia versus superimposed preeclampsia up to 37 weeks.
25386488 - Is surgical intervention for ectopic pregnancy in a low resource set-up avoidable?
22036528 - Galectins: guardians of eutherian pregnancy at the maternal-fetal interface.
6618278 - Severe acquired antithrombin iii deficiency in relation to hepatic and renal insufficie...
24581338 - Mefloquine safety and tolerability in pregnancy: a systematic literature review.
15589888 - Ca-125 serum levels and pregnancy outcome in in vitro fertilization.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Molecular reproduction and development     Volume:  46     ISSN:  1040-452X     ISO Abbreviation:  Mol. Reprod. Dev.     Publication Date:  1997 Apr 
Date Detail:
Created Date:  1997-06-10     Completed Date:  1997-06-10     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8903333     Medline TA:  Mol Reprod Dev     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  507-14     Citation Subset:  IM    
Department of Biochemistry and Biophysics, Iowa State University, Ames 50011, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Acute-Phase Proteins / biosynthesis*
Amniotic Fluid / metabolism
Blotting, Northern
Blotting, Western
Epithelium / metabolism
Gene Expression Regulation, Developmental
Labor, Obstetric / physiology*
Liver / metabolism
Oncogene Proteins / biosynthesis*
RNA, Messenger / biosynthesis
Uterus / metabolism*
Reg. No./Substance:
0/Acute-Phase Proteins; 0/Lipocalins; 0/Oncogene Proteins; 0/RNA, Messenger; 126469-30-5/Lcn2 protein, mouse

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Uterine preparation for implantation in the mouse is associated with coordinate expression of estrog...
Next Document:  Development of a positive method for male stem cell-mediated gene transfer in mouse and pig.