Document Detail


Utero-ovarian interaction in the regulation of reproductive function.
MedLine Citation:
PMID:  10027608     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The physiological regulation of fertile reproductive cycle in mammals depends on interactions between hypothalamus-pituitary, ovarian and uterine stimuli. Over the past 20 years, much has been learned about the interrelation between the affluent and effluent lymph and vascular drainage in and around both ovarian and uterine tissues. An essential feature in the regulation of the fertile cycle is the functional status of the ovary, particularly the corpus luteum. During the time of implantation and the early pregnancy, an active corpus luteum is essential. As human chorionic gonadotrophin (HCG) is important in the maintenance of the corpus luteum, we investigated if it was produced by the cyclic endometrium. Immunohistochemical and in-situ hybridization reactions were performed but neither identified the presence of HCG during the proliferative phase. Positive staining and beta-human chorionic gonadotrophin (beta-HCG) mRNA were observed during the secretory phase in the glandular cells of the endometrium. The results were confirmed by Western blotting of secretory phase endometrium extracts and assessment of the functional secretory capacity of primary endometrial cultures. Polymerase chain reaction (PCR) investigations showed a positive result in the secretory phase. We postulate that, based on the very close morphological interrelation between the uterus and the ovary, the beta-HCG of the endometrium is the primary factor for the maintenance of the corpus luteum and early pregnancy.
Authors:
H Alexander; G Zimmermann; G W Wolkersdörfer; C Biesold; M Lehmann; J Einenkel; G Pretzsch; D Baier
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Human reproduction update     Volume:  4     ISSN:  1355-4786     ISO Abbreviation:  Hum. Reprod. Update     Publication Date:    1998 Sep-Oct
Date Detail:
Created Date:  1999-04-16     Completed Date:  1999-04-16     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  9507614     Medline TA:  Hum Reprod Update     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  550-9     Citation Subset:  IM    
Affiliation:
Department of Gynaecology and Obstetrics, University Leipzig, Germany.
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MeSH Terms
Descriptor/Qualifier:
Animals
Chorionic Gonadotropin / physiology*
Embryo Implantation
Endometrium / physiology*
Female
Homeostasis
Humans
Menstrual Cycle / physiology
Ovary / physiology*
Pregnancy
Reproduction / physiology*
Uterus / physiology*
Chemical
Reg. No./Substance:
0/Chorionic Gonadotropin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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