| Uterine transplantation research: laboratory protocols for clinical application. | |
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MedLine Citation:
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PMID: 21900333 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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The aim of this review is to summarize the state-of the-art methods that are used in clinical organ transplantation today, as well as the major findings of recent experimental UTx research regarding organ donation/retrieval, ischemic preservation, surgical techniques for anastomosis, immunosuppression and pregnancy. Absolute uterine factor infertility lacks treatment despite the major developments in infertility treatment and assisted reproduction. Concerning uterine factor infertile patients, genetic motherhood is only possible through gestational surrogacy. The latter can pose medical, ethical and legal concerns such as lack of control of life habits during surrogate pregnancy, economic motives for women to become surrogate mothers, medical/psychological pregnancy-related risks of the surrogate mother and uncertainties regarding the mother definition.. Thus, surrogacy is non-approved in large parts of the world. Recent advances in the field of solid organ transplantation and experimental uterus transplantation (UTx) provide a favourable and safe background in a scenario in which a human clinical UTx trial can take place. Protocols based on animal research over the last decade are described with a view to providing a scientifically-guided approach to human UTx as an experimental procedure in the future. |
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Authors:
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C Díaz-García; L Johannesson; A Enskog; A Tzakis; M Olausson; M Brännström |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-9-7 |
Journal Detail:
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Title: Molecular human reproduction Volume: - ISSN: 1460-2407 ISO Abbreviation: - Publication Date: 2011 Sep |
Date Detail:
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Created Date: 2011-9-8 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9513710 Medline TA: Mol Hum Reprod Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Obstetrics and Gynecology, Sahlgrenska Academy, University of Gothenburg, SE-41345 Sweden. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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