Document Detail

Uterine and placental angiogenesis in the Australian skinks, Ctenotus taeniolatus, and Saiphos equalis.
MedLine Citation:
PMID:  20432373     Owner:  NLM     Status:  MEDLINE    
The evolution of viviparity requires modifications to multiple integrated physiological features to support embryonic development during pregnancy. Embryonic growth during pregnancy is dependent upon the capacity of the uterine vascular system to satisfy increasing embryonic oxygen demand throughout gestation. We tested the hypothesis that total surface area of uterine blood vessels increases in concert with embryonic growth, and hence its oxygen demand, during gestation. We used immunofluorescence and laser-scanning confocal microscopy to quantify uterine microvascular density and morphology during gestation in the oviparous skink Ctenotus taeniolatus and in Saiphos equalis, a skink species with prolonged egg retention. For C. taeniolatus, vessel density (Nv) and vessel length-density (Lv) in the embryonic hemisphere of the uterus is 23% and 17% less, respectively, than that of S. equalis and vascular surface-area does not differ as a function of embryo stage. For S. equalis, overall Nv, Lv, and vessel diameter (Dv), does not change during the first half of gestation but increases by 36% (Nv), 44% (Lv), and 60% (Dv) by near-term embryo stages late in gestation. The chorioallantoic membrane of S. equalis increases in absolute size but vascular density does not differ as a function of embryo stage. The marked increase in uterine vascular density during late gestation coincides with the phase of rapid growth in embryo mass and concomitant increase in metabolic rate. Expansion of the uterine vascular bed in concert with embryo size and metabolism is likely to be an important transitional step in the evolution of viviparity.
Scott L Parker; Frank Manconi; Christopher R Murphy; Michael B Thompson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Anatomical record (Hoboken, N.J. : 2007)     Volume:  293     ISSN:  1932-8494     ISO Abbreviation:  Anat Rec (Hoboken)     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-04-30     Completed Date:  2010-08-10     Revised Date:  2010-09-09    
Medline Journal Info:
Nlm Unique ID:  101292775     Medline TA:  Anat Rec (Hoboken)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  829-38     Citation Subset:  IM    
Integrative Physiology Research Group, School of Biological Sciences, The University of Sydney, Sydney, New South Wales, Australia.
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MeSH Terms
Basal Metabolism / physiology
Chorioallantoic Membrane / blood supply,  embryology
Embryo, Nonmammalian / blood supply,  embryology
Embryonic Development / physiology*
Fluorescent Antibody Technique
Lizards / anatomy & histology*,  physiology
Microscopy, Confocal
Neovascularization, Physiologic / physiology*
Placenta / blood supply*,  physiology
Regional Blood Flow / physiology
Uterine Artery / anatomy & histology,  physiology
Uterus / blood supply*,  physiology
Viviparity, Nonmammalian / physiology*

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