| Uterine natural killer cells are immunogenic in syngeneic male mice. | |
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MedLine Citation:
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PMID: 18771804 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Uterine natural killer (uNK) cells expand rapidly during endometrial decidualization and account for 70% of leukocytes in early gestational uteri of humans and rodents. These cells make unique contributions to pregnancy, contributing to the success of embryo implantation and maintenance of decidual tissue that supports placental and fetal development. We postulated that uNK cells express molecules that are not shared by circulating NK (cNK) cells or other leukocytes and, therefore, would be immunogenic for male mice. We isolated viable uNK cells from gestation day 9 pregnant mice and inoculated them into syngeneic males. This induced antibodies reactive with mouse uNK cells but not with cNK cells or other lymphocytes. The antibodies reacted identically with uNK cells in tissue sections from five different mice strains from gestational day 7-12 and in pregnant rat uterus, suggesting that the recognized antigen should be a specific marker of uNK cell. Spleen cells from inoculated males were used subsequently to produce a monoclonal antibody reactive to a uNK cell surface antigen. These experiments confirm that uNK cells are a pregnancy-specific subset of NK cells expressing distinct surface antigen from those found in other tissues. |
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Authors:
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Marcia C Bizinotto; Wirla M S C Tamashiro; Dirce L Gabriel; Aureo T Yamada |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-09-03 |
Journal Detail:
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Title: Journal of reproductive immunology Volume: 79 ISSN: 0165-0378 ISO Abbreviation: J. Reprod. Immunol. Publication Date: 2008 Oct |
Date Detail:
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Created Date: 2008-10-20 Completed Date: 2009-01-06 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8001906 Medline TA: J Reprod Immunol Country: Ireland |
Other Details:
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Languages: eng Pagination: 18-25 Citation Subset: IM |
Affiliation:
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Laboratory of Cytochemistry and Immunocytochemistry, Department of Histology and Embryology, Institute of Biology, University of Campinas (UNICAMP), 13083-970 Campinas, SP, Brazil. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antibodies / analysis Antigens, CD56 / analysis Female Immunohistochemistry Killer Cells, Natural / immunology* Male Mice Mice, Inbred Strains Pregnancy Rats Rats, Wistar Uterus / immunology* |
| Chemical | |
Reg. No./Substance:
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0/Antibodies; 0/Antigens, CD56 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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