Document Detail

Uterine leukocytes: key players in pregnancy.
MedLine Citation:
PMID:  10873709     Owner:  NLM     Status:  MEDLINE    
In species with hemochorial placentation, which includes humans, mice and rats, antigen-specific T and B lymphocytes which are responsible for acquired immunity are virtually absent from the maternal-fetal interface. In contrast, non-antigen specific natural killer cells and macrophages which provide innate immunity are abundant and highly specialized. Autocrine/paracrine factors such as steroid and polypeptide hormones, prostaglandins and anti-inflammatory cytokines that are present in the uterine environment during pregnancy re-program their secretory profiles. Recent studies using transgenic mice and other approaches indicate that these environmentally modified leukocytes have major pregnancy-associated functions that include facilitation of implantation, modulation of the maternal uterine vasculature, supply of growth factors to the placenta, promotion of trophoblast differentiation and facilitation of parturition.
J S Hunt; M G Petroff; T G Burnett
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Seminars in cell & developmental biology     Volume:  11     ISSN:  1084-9521     ISO Abbreviation:  Semin. Cell Dev. Biol.     Publication Date:  2000 Apr 
Date Detail:
Created Date:  2000-09-14     Completed Date:  2000-09-14     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9607332     Medline TA:  Semin Cell Dev Biol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  127-37     Citation Subset:  IM    
Copyright Information:
Copyright 2000 Academic Press.
The Department of Anatomy and Cell Biology, University of Kansas School of Medicine, 3901 Rainbow Boulevard, Kansas City, Kansas, 66160-7400, USA.
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MeSH Terms
Cytokines / genetics,  physiology
Leukocytes / physiology*
Maternal-Fetal Exchange / genetics,  physiology
Mice, Transgenic
Placenta / cytology,  physiology
Receptors, Growth Factor / genetics,  physiology
Uterus / blood supply,  cytology*
Grant Support
Reg. No./Substance:
0/Cytokines; 0/Receptors, Growth Factor

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