| Uterine leukocytes: key players in pregnancy. | |
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MedLine Citation:
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PMID: 10873709 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In species with hemochorial placentation, which includes humans, mice and rats, antigen-specific T and B lymphocytes which are responsible for acquired immunity are virtually absent from the maternal-fetal interface. In contrast, non-antigen specific natural killer cells and macrophages which provide innate immunity are abundant and highly specialized. Autocrine/paracrine factors such as steroid and polypeptide hormones, prostaglandins and anti-inflammatory cytokines that are present in the uterine environment during pregnancy re-program their secretory profiles. Recent studies using transgenic mice and other approaches indicate that these environmentally modified leukocytes have major pregnancy-associated functions that include facilitation of implantation, modulation of the maternal uterine vasculature, supply of growth factors to the placenta, promotion of trophoblast differentiation and facilitation of parturition. |
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Authors:
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J S Hunt; M G Petroff; T G Burnett |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S.; Review |
Journal Detail:
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Title: Seminars in cell & developmental biology Volume: 11 ISSN: 1084-9521 ISO Abbreviation: Semin. Cell Dev. Biol. Publication Date: 2000 Apr |
Date Detail:
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Created Date: 2000-09-14 Completed Date: 2000-09-14 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 9607332 Medline TA: Semin Cell Dev Biol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 127-37 Citation Subset: IM |
Copyright Information:
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Copyright 2000 Academic Press. |
Affiliation:
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The Department of Anatomy and Cell Biology, University of Kansas School of Medicine, 3901 Rainbow Boulevard, Kansas City, Kansas, 66160-7400, USA. jhunt@kumc.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cytokines / genetics, physiology Female Humans Leukocytes / physiology* Maternal-Fetal Exchange / genetics, physiology Mice Mice, Transgenic Placenta / cytology, physiology Pregnancy Receptors, Growth Factor / genetics, physiology Uterus / blood supply, cytology* |
| Grant Support | |
ID/Acronym/Agency:
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HD24212/HD/NICHD NIH HHS; HD26429/HD/NICHD NIH HHS; HD29156/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Cytokines; 0/Receptors, Growth Factor |
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