| Uterine glands provide histiotrophic nutrition for the human fetus during the first trimester of pregnancy. | |
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MedLine Citation:
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PMID: 12050279 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Providing adequate nutrition to the fetus is key to a successful pregnancy. The interstitial form of implantation displayed by the human blastocyst is generally associated with early onset of maternal blood flow to the developing placenta, and hence hemotrophic exchange. However, the recent finding that the maternal intraplacental circulation is not fully established until the third month of gestation suggests that human fetal nutrition may be initially histiotrophic. We therefore investigated activity of the uterine glands during early pregnancy. We demonstrate here that these glands remain active until at least wk 10 of pregnancy, and that their secretions are delivered freely into the placental intervillous space. We also demonstrate phagocytic uptake by the placental syncytiotrophoblast of two glycoproteins, the mucin MUC-1 and glycodelin A, synthesized in the maternal glands. Glycodelin was also detected within the epithelium of the secondary yolk sac lining the exocoelomic cavity, indicating that the yolk sac may play an important role in nutrient exchange before vascularisation of the chorionic villi. Our findings demonstrate that the uterine glands are an important source of nutrients during organogenesis, when metabolism is essentially anaerobic. |
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Authors:
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Graham J Burton; Adrian L Watson; Joanne Hempstock; Jeremy N Skepper; Eric Jauniaux |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Journal of clinical endocrinology and metabolism Volume: 87 ISSN: 0021-972X ISO Abbreviation: J. Clin. Endocrinol. Metab. Publication Date: 2002 Jun |
Date Detail:
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Created Date: 2002-06-06 Completed Date: 2002-07-03 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0375362 Medline TA: J Clin Endocrinol Metab Country: United States |
Other Details:
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Languages: eng Pagination: 2954-9 Citation Subset: AIM; IM |
Affiliation:
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Department of Anatomy, University of Cambridge, Downing Street, Cambridge CB2 3DY, United Kingdom. gjb2@cam.ac.uk |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Endocrine System
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secretion* Female Fetus / physiology* Glycoproteins / metabolism Humans Microscopy, Electron Mucin-1 / metabolism Nutritional Physiological Phenomena / physiology* Pregnancy / physiology* Pregnancy Proteins / metabolism Pregnancy Trimester, First Uterus / secretion*, ultrastructure Yolk Sac / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Glycoproteins; 0/Mucin-1; 0/PAEP protein, human; 0/Pregnancy Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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