Document Detail


Uterine flow velocity waveform shape as an indicator of maternal and placental development failure mechanisms: a model-based synthesizing approach.
MedLine Citation:
PMID:  8590189     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
High pulsatility indices (PIs) and/or notches on the Doppler flow velocity waveforms of the uterine artery have been interpreted as indications of high placental flow impedance, and are known to be associated with poor fetal outcome. A software model of the uteroplacental blood path and its use to investigate possible interactions within the uteroplacental unit in more detail are described. Increasing transcotyledonary resistance to represent intervillous obstruction raised the cotyledonary core pressure and spiral artery PI. Increased spiral artery flow resistance, representing failed spiral artery invasion, reduced the cotyledonary core pressure and reduced the spiral artery PI. In vivo, such changes in cotyledonary core pressure would modify the transplacental water balance, promoting oligohydramnios for spiral artery invasion failure and polyhydramnios for villous obstruction. Both mechanisms increased the uterine and arcuate PI, but failed to produce a notch. It was found that notch formation depended on terms representing increased compliance (distensibility) of the uterine and/or arcuate artery walls, which have no direct effect on uteroplacental mean flow. The same mechanism steepened and increased uterine artery peak systolic flow, contributing to increased PI. The notch phenomenon seems to be an indicator of abnormal maternal artery wall status, independent of placental obstructive mechanisms, which can mask obstructive PI changes. Computer analysis of the frequency index profile should allow separation.
Authors:
D G Talbert
Related Documents :
1539699 - Right and left ventricular function in fetal sheep exposed to long-term high-altitude h...
23764429 - Influences of the depth-dependent material inhomogeneity of articular cartilage on the ...
15364119 - Spiral artery associated restricted growth (spaarg): a computer model of pathophysiolog...
1418139 - Reduction in the middle cerebral artery pulsatility index after decompression of polyhy...
9532999 - The reliability of catheter-tip transducers for the measurement of intrauterine pressur...
1561559 - The effect of continuous low-dose epidural analgesia on uterine work during the active ...
24913569 - Accumulation of microvascular target organ damage in newly diagnosed hypertensive patie...
3372409 - Recovery of the ventilatory response to hypoxia in normal adults.
6743469 - The relaxant action of hymecromone and lignocaine on induced spasm of the bile duct sph...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology     Volume:  6     ISSN:  0960-7692     ISO Abbreviation:  Ultrasound Obstet Gynecol     Publication Date:  1995 Oct 
Date Detail:
Created Date:  1996-03-28     Completed Date:  1996-03-28     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9108340     Medline TA:  Ultrasound Obstet Gynecol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  261-71     Citation Subset:  IM    
Affiliation:
Institute of Obstetrics and Gynaecology, Royal Postgraduate Medical School, Queen Charlotte's and Chelsea Hospital, London, UK.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Computer Simulation*
Female
Humans
Placental Circulation* / physiology
Pregnancy
Ultrasonography, Doppler*
Ultrasonography, Prenatal*
Vascular Resistance
Comments/Corrections
Comment In:
Ultrasound Obstet Gynecol. 1995 Oct;6(4):237-9   [PMID:  8590185 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Fetal midgut herniation into the umbilical cord: improved definition of ventral abdominal anomaly wi...
Next Document:  Micro-bead embolization of uterine spiral arteries and changes in uterine arterial flow velocity wav...