Document Detail

Uterine fibroids affect pregnancy outcome in women over 30 years old: role of other risk factors.
MedLine Citation:
PMID:  23126572     Owner:  NLM     Status:  Publisher    
Abstract Objective: To evaluate the pregnancy outcome in women >30 years old with uterine fibroids also considering other possible concomitant risk factors. Methods: A multicentric, observational and retrospective study was conducted. All women were asked to complete a questionnaire while they were in hospital and the outcome of pregnancy was investigated. Results: Women with uterine fibroids before pregnancy were more frequently >35 years old and in their clinical history before pregnancy showed more pelvic pain, polliachiuria, previous pelvic surgery, hypermenorrhea and dysmenorrhea, than control women (P<0.0001). During pregnancy patients with uterine fibroids showed significantly more threatened preterm birth and preterm birth, weight gain, hyperemesis, gestational hypertension and post partum bleeding and showed more often requirement for emergency cesarean section (P<0.0001). The multivariate logistic regression model used for evaluating the effect of clinical parameters on outcome of pregnancy showed that age > 35 years, pelvic pain, work, weight gain, hyperemesis, threatened miscarriage and threatened preterm birth were significantly correlated with unfavorable pregnancy outcome, independently of the presence of uterine fibroids (P<0.0001). Conclusions: The present study confirming a more frequent negative pregnancy outcome in presence of uterine fibroids, showed that other risk factors may affect pregnancy and delivery outcome in women aging > 30 years old.
Nathalie Conti; Claudia Tosti; Serena Pinzauti; Tiziana Tomaiuolo; Gabriele Cevenini; Filiberto Maria Severi; Mariarosaria Di Tommaso; Felice Petraglia
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-5
Journal Detail:
Title:  The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians     Volume:  -     ISSN:  1476-4954     ISO Abbreviation:  J. Matern. Fetal. Neonatal. Med.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-6     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101136916     Medline TA:  J Matern Fetal Neonatal Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Department of Molecular and Developmental Medicine, University of Siena, Siena, Italy.
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