| Uterine and fetal hemodynamics and fetal cardiac function after atenolol and pindolol infusion. A randomized study. | |
| | |
MedLine Citation:
|
PMID: 8582495 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: To evaluate the short-term effects of intravenously given atenolol and pindolol on utero- and umbilicoplacental vascular impedance, fetal hemodynamics and cardiac function in patients suffering from pregnancy-induced hypertension. STUDY DESIGN: A total of 24 women were randomized to receive atenolol or pindolol infusion. By using pulsed color Doppler techniques, uterine, placental arcuate, umbilical fetal middle cerebral and renal arteries were examined before, at the end and 30 min after the end of infusion. Pulsatility indices (PI) were calculated to assess vascular impedance. Fetal myocardial function was evaluated by using pulsed Doppler and M-mode echocardiography. Peak systolic velocities from the ascending aorta and pulmonary trunk, and also inner diameters and fractional shortenings of both ventricles were measured. RESULTS: Both drugs significantly decreased maternal blood pressure. Immediately after the infusion, maternal heart rate was significantly decreased in both groups; but the decrease was clearer and lasted longer in the atenolol group. Pindolol caused no changes in utero- or umbilicoplacental vascular impedance, while atenolol increased it in the nonplacental uterine artery. After atenolol infusion, PI in the umbilical artery was higher than after pindolol. Pindolol had no effects on fetal hemodynamics, while atenolol decreased PI value in the fetal renal artery. Peak systolic velocity in the pulmonary trunk was decreased after atenolol. Pindolol did not affect the fetal cardiac function. In subgroups with originally increased utero- or umbilicoplacental vascular impedance, the responses in uterine and umbilical vascular impedance and in fetal hemodynamics and cardiac function after atenolol and pindolol were different compared to whole groups. CONCLUSION: Differently acting antihypertensive agents seem to affect differently uteroplacental vascular impedance. Atenolol may have some direct effects on fetal hemodynamics and cardiac function. According to our results, pindolol seems to be more preferable in the treatment of pregnancy-induced hypertension than atenolol. |
| | |
Authors:
|
J Räsänen; P Jouppila |
Related Documents
:
|
12164565 - A long-term transdermal nitric oxide donor improves uteroplacental circulation in women... 8979295 - The effect of hypercapnia and hypercapnia associated with central cooling on breathing ... 8498445 - Effects of labetalol on uterine blood flow and cardiovascular hemodynamics in the hyper... 20562335 - Wave intensity analysis of right ventricular and pulmonary vascular contributions to hi... 17946685 - Improving the detection of stage i pressure ulcers by enhancing digital color images. 6641025 - Hemodynamic changes during hemodialysis: role of dialyzate. |
Publication Detail:
|
Type: Clinical Trial; Journal Article; Randomized Controlled Trial |
Journal Detail:
|
Title: European journal of obstetrics, gynecology, and reproductive biology Volume: 62 ISSN: 0301-2115 ISO Abbreviation: Eur. J. Obstet. Gynecol. Reprod. Biol. Publication Date: 1995 Oct |
Date Detail:
|
Created Date: 1996-03-19 Completed Date: 1996-03-19 Revised Date: 2007-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0375672 Medline TA: Eur J Obstet Gynecol Reprod Biol Country: IRELAND |
Other Details:
|
Languages: eng Pagination: 195-201 Citation Subset: IM |
Affiliation:
|
Department of Obstetrics and Gynecology, University of Oulu, Finland. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adrenergic beta-Antagonists
/
adverse effects* Adult Antihypertensive Agents / adverse effects* Atenolol / adverse effects Female Fetal Heart / drug effects* Hemodynamics / drug effects* Humans Infusions, Intravenous Pindolol / adverse effects Pregnancy Pregnancy Complications, Cardiovascular / drug therapy* Uterus / drug effects* |
| Chemical | |
Reg. No./Substance:
|
0/Adrenergic beta-Antagonists; 0/Antihypertensive Agents; 13523-86-9/Pindolol; 29122-68-7/Atenolol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Lactoferrin as a sensitive blood marker of neutrophil activation in normal pregnancies.
Next Document: High delivery intervention rates in nulliparous women over age 35.