Document Detail

Uterine and fetal asphyxia monitoring in parturient sows treated with oxytocin.
MedLine Citation:
PMID:  15721664     Owner:  NLM     Status:  MEDLINE    
Oxytocin is used to induce and control parturition, nevertheless, the increase of uterine contractions decreases blood flow and gaseous exchange through the womb predisposing to intra-partum mortality. The objective of the present study was to evaluate the effect of oxytocin on myometrial activity, fetal intrauterine hypoxia and postnatal asphyxia in sows during farrowing. Hybrid (n = 120) sows approaching the time of farrowing were randomly assigned in two groups of 60 animals each. Group I (G(1): control) was treated IM with saline solution and Group II (G(2)) was injected IM with oxytocin (1IU/6kg LW) as a single dose at birth of the first piglet. Both average number of myometrial contractions and intensity in G(2) were greater (P < 0.01) as compared with G(1). The mean of intra-partum stillbirths (IPS's) and those where fetal cardiac frequency (FCF) or heart beats, could not be detected after birth, were greater (P < 0.01) in G(2) as compared with G(1). The average decelerations of FCF known as dips II, which indicate severe hypoxia, was greater in G(2) (P < 0.01) as compared with that of G(1). There was a greater (P < 0.01) number of intra-partum stillbirths, stained with severe meconium in G(2) when compared with G(1). Oxytocin treatment increased (P < 0.01) the number of pigs born alive with ruptured umbilical cords and those with different grades of meconium staining on their skin. It was concluded that administration of oxytocin at the onset of parturition increased the myometrial activity, decreased fetal cardiac frequency, predisposed the rupture of umbilical cords and the degree of meconium staining, and increased intra-partum mortality.
Daniel Mota-Rojas; Julio Martínez-Burnes; Ma Elena Trujillo; Alfonso López; Ana M Rosales; Ramiro Ramírez; Héctor Orozco; Angeles Merino; María Alonso-Spilsbury
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Animal reproduction science     Volume:  86     ISSN:  0378-4320     ISO Abbreviation:  Anim. Reprod. Sci.     Publication Date:  2005 Mar 
Date Detail:
Created Date:  2005-02-21     Completed Date:  2005-04-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7807205     Medline TA:  Anim Reprod Sci     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  131-41     Citation Subset:  IM    
Laboratorio de Etología y Producción Porcina, Universidad Autónoma Metropolitana-Xochimilco, Calzada del hueso 1100, Col. Villa Quietud, D.F. 04960, México.
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MeSH Terms
Animals, Newborn
Fetal Hypoxia / chemically induced,  veterinary*
Fetal Monitoring / veterinary
Heart Rate, Fetal / drug effects,  physiology
Meconium / physiology
Myometrium / drug effects
Oxytocin / adverse effects,  pharmacology*
Parturition / drug effects*,  physiology
Pregnancy Outcome / veterinary
Random Allocation
Swine / physiology*
Uterine Contraction / drug effects*,  physiology
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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