| Uterine electromyography and light-induced fluorescence in the management of term and preterm labor. | |
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MedLine Citation:
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PMID: 12383910 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Understanding the physiology of the uterus and cervix during term and preterm parturition is crucial for developing methods to control their function and is essential to solving clinical problems related to labor. To date, only crude, inaccurate, and subjective methods are used to assess changes in uterine and cervical function in pregnancy. METHODS: In the past several years, we have developed noninvasive methods to quantitatively evaluate the uterus and cervix based on recording of uterine electrical signals from the abdominal surface (uterine electromyography) and measurement of light-induced fluorescence (LIF) of cervical collagen (Collascope), respectively. Both methods are rapid and allow immediate assessment of uterine contractility and cervical ripening. RESULTS: Studies in animals and humans indicated that uterine and cervical performance can be monitored successfully during pregnancy using those approaches and that these techniques can be used during labor to better define management in a variety of conditions associated with labor. CONCLUSION: The potential benefits of the proposed instrumentation and methods include reducing the rate of preterm delivery, improving maternal and perinatal outcome, monitoring treatment, decreasing cesarean rate and providing research methods to understand uterine and cervical function. |
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Authors:
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R E Garfield; H Maul; W Maner; C Fittkow; G Olson; L Shi; G R Saade |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review |
Journal Detail:
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Title: Journal of the Society for Gynecologic Investigation Volume: 9 ISSN: 1071-5576 ISO Abbreviation: J. Soc. Gynecol. Investig. Publication Date: 2002 Sep-Oct |
Date Detail:
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Created Date: 2002-10-17 Completed Date: 2003-03-07 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 9433806 Medline TA: J Soc Gynecol Investig Country: United States |
Other Details:
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Languages: eng Pagination: 265-75 Citation Subset: IM |
Affiliation:
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Reproductive Sciences, Department of Obstetrics and Gynecology, University of Texas Medical Branch, Galveston, Texas 77555-1062, USA. rgarfiel@utmb.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cervix Uteri / chemistry, physiopathology Collagen / chemistry Electromyography* Female Fluorescence* Humans Labor, Obstetric* Light Myometrium / physiopathology Obstetric Labor, Premature / physiopathology*, prevention & control Pregnancy Spectrometry, Fluorescence Uterine Contraction Uterus / physiopathology* |
| Grant Support | |
ID/Acronym/Agency:
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5 R01 HD37480/HD/NICHD NIH HHS; M01 RR00073/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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9007-34-5/Collagen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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