Document Detail


Uterine contraction frequency before and after successful tocolytic therapy for preterm uterine contractions.
MedLine Citation:
PMID:  14686015     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To examine the association between prelabor uterine contraction frequency (UCF) and the success of tocolytic therapy for preterm labor (PTL). STUDY DESIGN: Eleven centers conducted a prospective, observational study of UCF recorded between 22(0/7) and 36(6/7) weeks' gestational age or until delivery > or = 2 times/d on > or = 2 d/wk in women with singleton pregnancies with and without risk factors for preterm birth. Uterine contraction data obtained from patients diagnosed with PTL allowed comparison of mean UCF both before and after an acute episode of PTL treated with either intravenous, subcutaneous or oral tocolysis. The signed rank test was used to analyze differences in UCF before and after tocolytic therapy and between women who were or were not successfully treated with a labor-inhibiting agent. RESULTS: Of 454 enrolled women, 128 were diagnosed with PTL, and 74 were successfully treated with a labor-inhibiting agent. The mean UCF preceding PTL was not different between those women successfully treated and those who delivered as a consequence of the PTL episode. There was no difference (P = .653) in mean UCF between the week before PTL (UCF 0.60 +/- 0.8, median 0.30) and the first week of monitoring after successful tocolysis (UCF 0.82 +/- 1.4, median 0.27). CONCLUSION: The mean UCF immediately preceding PTL does not predict tocolytic success or failure.
Authors:
Roger B Newman; Francee Johnson; Anita Das; Robert L Goldenberg; Melissa Swain; Atef Moawad; Baha M Sibai; Steve N Caritis; Menachem Miodovnik; Richard H Paul; Mitchell P Dombrowski; Beth A Collins Sharp; Molly Fischer
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Publication Detail:
Type:  Journal Article; Multicenter Study; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of reproductive medicine     Volume:  48     ISSN:  0024-7758     ISO Abbreviation:  J Reprod Med     Publication Date:  2003 Nov 
Date Detail:
Created Date:  2003-12-22     Completed Date:  2004-03-29     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0173343     Medline TA:  J Reprod Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  843-9     Citation Subset:  IM    
Affiliation:
Department of Obstetrics and Gynecology, Medical University of South Carolina, 96 Jonathan Lucas Street, Suite 634, P.O. Box 250619, Charleston, SC 29425, USA. newmanr@musc.edu
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MeSH Terms
Descriptor/Qualifier:
Adult
Alabama
California
Case-Control Studies
Chicago
Cohort Studies
District of Columbia
Female
Gestational Age
Humans
Maryland
Michigan
North Carolina
Obstetric Labor, Premature / prevention & control*
Ohio
Pennsylvania
Pregnancy
Prospective Studies
South Carolina
Tennessee
Tocolytic Agents / administration & dosage*
Uterine Contraction / physiology*
Grant Support
ID/Acronym/Agency:
HD 19897/HD/NICHD NIH HHS; HD 21410/HD/NICHD NIH HHS; HD 21414/HD/NICHD NIH HHS; HD 21434/HD/NICHD NIH HHS; HD 27860/HD/NICHD NIH HHS; HD 27861/HD/NICHD NIH HHS; HD 27869/HD/NICHD NIH HHS; HD 27883/HD/NICHD NIH HHS; HD 27889/HD/NICHD NIH HHS; HD 27905/HD/NICHD NIH HHS; HD 27915/HD/NICHD NIH HHS; HD 27917/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
0/Tocolytic Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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