| Uterine cervical inflammatory cytokines, interleukin-6 and -8, as predictors of miscarriage in recurrent cases. | |
| | |
MedLine Citation:
|
PMID: 17845205 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
PROBLEM: Inflammatory changes frequently occur in cases of second trimester miscarriage or pre-term delivery, but little attention has been paid to this association with recurrent miscarriage. As interleukin-6 and interleukin-8 are inflammatory cytokines reported to be associated with bacterial vaginosis, intrauterine infections, and pre-term delivery, we here investigated whether they might have predictive value for spontaneous abortion in recurrent cases. METHOD OF STUDY: Cervical mucus and sera were collected at 4-5 weeks' gestation from a total of 59 patients with a history of two or more unexplained consecutive first trimester miscarriages, and examined by enzyme-linked immunosorbent assay. Patients then were followed up without medication and their pregnancy outcomes were compared with the test results. RESULTS: Of a total of 59 patients, 13 (22%) miscarried subsequently. Both IL-6 and IL-8 in cervical mucus were significantly higher in patients who miscarried subsequently than in those who had a live birth. In addition, there was no correlation between cervical mucus and serum concentrations of IL-6 and IL-8 take at the same time, and there was no relation with serum IL-6 and IL-8 levels between the two groups. CONCLUSION: Cervical IL-6 and IL-8 might have predictive value for cases of recurrent miscarriage. |
| | |
Authors:
|
Yukio Hattori; Tamao Nakanishi; Yasuhiko Ozaki; Kyoko Nozawa; Takeshi Sato; Mayumi Sugiura-Ogasawara |
Related Documents
:
|
7644635 - Spontaneously changing gravid cervix: clinical implications and prognostic features. 17339775 - Prediction of preterm delivery among women with threatened preterm labor. 8616965 - The diagnosis of preterm labor and the prediction of preterm delivery. 3461665 - Interaction between prostaglandin e2 and noradrenalin on collagen synthesis in human ce... 11566285 - How contraceptive use patterns differ by pregnancy intention: implications for counseling. 7450565 - Humoral endorphin in human body fluids during pregnancy. |
Publication Detail:
|
Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: American journal of reproductive immunology (New York, N.Y. : 1989) Volume: 58 ISSN: 1046-7408 ISO Abbreviation: Am. J. Reprod. Immunol. Publication Date: 2007 Oct |
Date Detail:
|
Created Date: 2007-09-11 Completed Date: 2007-10-25 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8912860 Medline TA: Am J Reprod Immunol Country: Denmark |
Other Details:
|
Languages: eng Pagination: 350-7 Citation Subset: IM |
Affiliation:
|
Department of Obstetrics and Gynecology, Nagoya City University Medical School, Nagoya, Japan. yahttori@med.nagoya-cu.ac.jp |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Abortion, Habitual
/
diagnosis*,
metabolism Adult Cervix Mucus / chemistry* Cervix Uteri / chemistry* Female Humans Interleukin-6 / analysis*, blood Interleukin-8 / analysis*, blood Live Birth Predictive Value of Tests Pregnancy Pregnancy Trimester, First / metabolism Sensitivity and Specificity Up-Regulation |
| Chemical | |
Reg. No./Substance:
|
0/IL6 protein, human; 0/Interleukin-6; 0/Interleukin-8 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Value of combined clinical information and thyroid peroxidase antibodies in pregnancy for the predic...
Next Document: RCAS1 decidual immunoreactivity in severe pre-eclampsia: immune cell presence and activity.