Document Detail

Uterine artery Doppler velocimetry and obstetric outcomes in connective tissue diseases diagnosed during the first trimester of pregnancy.
MedLine Citation:
PMID:  22961285     Owner:  NLM     Status:  Publisher    
OBJECTIVE: To evaluate the effect of connective tissue disease (CTD) diagnosed during the first trimester on uterine arteries (UtA) Doppler velocities and on pregnancy outcomes. METHOD: Pregnant women were screened for CTDs during the first trimester, using a questionnaire, testing for autoantibodies, rheumatologic examination and UtA Doppler evaluations. RESULTS: Out of 3932 women screened, 491 (12.5%) were screened positive at the questionnaire; of them, 165(33.6%) tested positive for autoantibodies, including 66 eventually diagnosed with undifferentiated connective tissue disease (UCTD), 28 with a definite CTD and 71 with insufficient criteria for a diagnosis. Controls were 326 women screened negative for autoantibodies. In logistic analysis, women diagnosed with either UCTD (OR = 7.9, 95% CI = 2.3-27.3) or overt CTD (OR = 24.9, 95% CI = 6.7-92.4), had increased rates of first trimester bilateral UtA notches compared with controls. The rates of bilateral UtA notches persisting in the second (15/94 vs 0/326, p < 0.001) and third trimesters (7/94 vs 0/326, p < .001) were higher among women with CTDs than in controls. The risk of complications (preeclampsia, fetal growth restriction, prematurity, diabetes, fetal loss) was higher (OR = 7.8, 95% CI = 3.6-17.0) among women with CTDs than in controls. CONCLUSION: Women with undiagnosed CTDs have higher rates of bilateral UtA Doppler notches throughout pregnancy and increased rates of adverse pregnancy outcomes than controls. © 2012 John Wiley & Sons, Ltd.
Fausta Beneventi; Elena Locatelli; Véronique Ramoni; Roberto Caporali; Carlo Maurizio Montecucco; Margherita Simonetta; Chiara Cavagnoli; Maria Ferrari; Arsenio Spinillo
Related Documents :
23245345 - Quantitative elisas for serum soluble lhcgr and hcg-lhcgr complex: potential diagnostic...
11934535 - Pregnancy outcome of women who failed appointments at a teratogen information service c...
17938085 - Abortion policies and practices in chile: ambiguities and dilemmas.
24983685 - Precocious cervical ripening as a screening target to predict spontaneous preterm deliv...
11100305 - Ovulation induction.
10883395 - Enzyme-histochemically detectable glucose-6-phosphatase is present in chorion laeve tro...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-9-7
Journal Detail:
Title:  Prenatal diagnosis     Volume:  -     ISSN:  1097-0223     ISO Abbreviation:  Prenat. Diagn.     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-9-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8106540     Medline TA:  Prenat Diagn     Country:  -    
Other Details:
Languages:  ENG     Pagination:  1-8     Citation Subset:  -    
Copyright Information:
© 2012 John Wiley & Sons, Ltd.
Department of Obstetrics and Gynecology, San Matteo Hospital, Pavia, Italy.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  [A case study; ethnicity and clozapine, a risky combination?].
Next Document:  Iridium nanoparticles stabilized by metal organic frameworks (IrNPs@ZIF-8): synthesis, structural pr...