Document Detail


Uterine artery Doppler and sFlt-1/PlGF ratio: usefulness in the diagnosis of pre-eclampsia.
MedLine Citation:
PMID:  23303638     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
OBJECTIVE: to evaluate the performance of the mean pulsatility index of uterine arteries (mPI-UtA) and the automated measurement of sFlt-1/PlGF ratio at suspicion or diagnosis of pre-eclampsia (PE). METHODS: singleton pregnancies with PE (n=60), diagnosed following current recommendations, or with suspected PE (n=32), defined either by i) blood pressure (BP) ≥160/100 mmHg or ii) BP≥140/90 mmHg or proteinuria together with suggestive clinical symptoms or iii) intrauterine growth restriction (IUGR) <34+0 weeks, were enrolled and mPI-UtA and sFlt-1/PlGF ratio were measured. Values >95(th) centile were considered abnormal. All cases were classified according to the occurrence of PE and/or IUGR and subclassified depending on gestational age at delivery in early (<34+0 weeks) and late (≥34+0 weeks). RESULTS: PE was finally confirmed in 72 cases, of which 32 had early delivery. Isolated IUGR was diagnosed in 9 early and 1 late cases, while the remaining 10 were late deliveries without PE or IUGR. In pregnancies in which PE and IUGR were excluded, mPI-UtA was abnormal in 40%, but sFlt-1/PlGF ratio was normal in 100%. In early PE, mPI-UtA at diagnosis was abnormal in 100% cases with IUGR and in 91% without IUGR, while sFlt-1/PlGF was abnormal in 100% and 96%, respectively. In late PE, mPI-UtA was abnormal in 50% and 37% cases with and without IUGR while sFlt-1/PlGF ratio was abnormal in 50% and 26%, respectively. CONCLUSION: in early PE, abnormal mPI-UtA and sFlt-1/PlGF ratio are common features. In late PE, mPI-UtA is not useful while the sFlt-1/PlGF ratio shows high specificity with low sensitivity to confirm PE.
Authors:
Pi Gómez-Arriaga; I Herraiz; Ea López-Jiménez; E Gómez-Montes; B Denk; A Galindo
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-10
Journal Detail:
Title:  Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology     Volume:  -     ISSN:  1469-0705     ISO Abbreviation:  Ultrasound Obstet Gynecol     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9108340     Medline TA:  Ultrasound Obstet Gynecol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2013 ISUOG. Published by John Wiley & Sons, Ltd.
Affiliation:
Fetal Medicine Unit-SAMID, Department of Obstetrics and Gynaecology. Hospital Universitario "12 de Octubre", Universidad Complutense de Madrid, Spain.
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