Document Detail

Uterine artery Doppler in the investigation of pregnancies with raised maternal serum alpha-fetoprotein.
MedLine Citation:
PMID:  1695525     Owner:  NLM     Status:  MEDLINE    
Uterine artery flow velocity waveforms (FVW) were obtained prospectively by continuous wave Doppler at 18-22 weeks gestation from 98 women with an unexplained elevation in maternal serum alpha-fetoprotein (MSAFP). A notch in either the left or right uterine artery FVW was present in 18 pregnancies of which seven resulted in perinatal death and six in the birth of very immature and/or severely growth retarded babies. Conversely, in 66 of 80 pregnancies the absence of a notch was associated with the livebirth of an infant beyond 32 weeks gestation, with a birthweight above the 5th centile. It is suggested that the presence of a notch in the uterine artery FVW is a good predictor of poor perinatal outcome.
A Aristidou; M C Van den Hof; S Campbell; K Nicolaides
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  British journal of obstetrics and gynaecology     Volume:  97     ISSN:  0306-5456     ISO Abbreviation:  Br J Obstet Gynaecol     Publication Date:  1990 May 
Date Detail:
Created Date:  1990-08-27     Completed Date:  1990-08-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7503752     Medline TA:  Br J Obstet Gynaecol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  431-5     Citation Subset:  AIM; IM    
Harris Birthright Research Centre for Fetal Medicine, King's College School of Medicine and Dentistry, London.
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MeSH Terms
Blood Flow Velocity
Fetal Death
Fetal Growth Retardation / physiopathology
Gestational Age
Infant, Newborn
Pregnancy Complications / blood*,  physiopathology
Pregnancy Outcome
Prospective Studies
Uterus / blood supply*
Vascular Resistance / physiology
alpha-Fetoproteins / analysis*
Reg. No./Substance:

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