Document Detail


Uterine and fetal blood flow indexes and fetal growth assessment after chronic estrogen suppression in the second half of baboon pregnancy.
MedLine Citation:
PMID:  20023123     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Although estrogen regulates important aspects of maternal cardiovascular physiology, the role of estrogen on uteroplacental and fetal blood flow is incompletely understood. This study tested the hypothesis that chronically suppressing endogenous estrogen production during the second half of baboon pregnancy alters uterine and fetal blood flow dynamics assessed by ultrasonography. Pregnant baboons were untreated or treated daily with the aromatase inhibitor letrozole or letrozole plus estradiol on days 100-160 of gestation (term = 184 days). Blood flow dynamics were determined by Doppler ultrasonography on day 60 and longitudinally between days 110 and 160 of gestation. Letrozole decreased maternal serum estradiol and estrone concentrations by 95% (P < 0.001). Fetal growth biometrical parameters increased (P < 0.001) between days 110 and 160 of gestation and were similar in untreated and letrozole-treated animals. Uterine, umbilical, and fetal middle cerebral artery pulsatility index and resistance index declined (P < 0.01) by 30-50% and uterine artery volume flow increased sixfold (P < 0.001) between days 60 and 160, but values were similar in untreated, letrozole-treated, and letrozole plus estradiol-treated baboons. Thus uterine and fetal artery blood flow indexes, uterine artery volume flow, and fetal growth were maintained at normal levels despite chronic estrogen suppression in the second half of baboon pregnancy. This suggests that elevated levels of endogenous estrogen are not required to maintain low impedance blood flow within the uteroplacental vascular bed during the second half of nonhuman primate pregnancy.
Authors:
Graham W Aberdeen; Ahmet A Baschat; Chris R Harman; Carl P Weiner; Patricia W Langenberg; Gerald J Pepe; Eugene D Albrecht
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2009-12-18
Journal Detail:
Title:  American journal of physiology. Heart and circulatory physiology     Volume:  298     ISSN:  1522-1539     ISO Abbreviation:  Am. J. Physiol. Heart Circ. Physiol.     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-02-25     Completed Date:  2010-04-02     Revised Date:  2014-09-17    
Medline Journal Info:
Nlm Unique ID:  100901228     Medline TA:  Am J Physiol Heart Circ Physiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  H881-9     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Aromatase Inhibitors / pharmacology
Blood Pressure / physiology
Body Weight / physiology
Estradiol / blood
Estrogens / deficiency*,  physiology
Female
Fetal Development / drug effects,  physiology*
Fetus / blood supply*
Models, Animal
Nitriles / pharmacology
Papio anubis
Placental Circulation / drug effects,  physiology
Pregnancy
Pregnancy, Animal / drug effects,  physiology*
Regional Blood Flow / drug effects,  physiology*
Triazoles / pharmacology
Umbilical Arteries / physiology
Uterus / blood supply*
Grant Support
ID/Acronym/Agency:
R01 HD-13294/HD/NICHD NIH HHS; R01 HD013294/HD/NICHD NIH HHS; R01 HD013294-30/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
0/Aromatase Inhibitors; 0/Estrogens; 0/Nitriles; 0/Triazoles; 112809-51-5/letrozole; 4TI98Z838E/Estradiol
Comments/Corrections

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