Document Detail


Uterine deletion of Trp53 compromises antioxidant responses in the mouse decidua.
MedLine Citation:
PMID:  22759378     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Preterm birth is a global health issue impacting millions of mothers and babies. However, the etiology of preterm birth is not clearly understood. Our recent finding that premature decidual senescence with terminal differentiation is a cause of preterm birth in mice with uterine Trp53 deletion, encoding p53 protein, led us to explore other potential factors that are related to preterm birth. Using proteomics approaches, here, we show that 183 candidate proteins show significant changes in deciduae with Trp53 deletion as compared with normal deciduae. Functional categorization of these proteins unveiled new pathways that are influenced by p53. In particular, down-regulation of a cluster of antioxidant enzymes in p53-deficient deciduae suggests that increased oxidative stress could be one cause of preterm birth in mice harboring uterine deletion of Trp53.
Authors:
Kristin E Burnum; Yasushi Hirota; Erin S Baker; Mikihiro Yoshie; Yehia M Ibrahim; Matthew E Monroe; Gordon A Anderson; Richard D Smith; Takiko Daikoku; Sudhansu K Dey
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2012-07-03
Journal Detail:
Title:  Endocrinology     Volume:  153     ISSN:  1945-7170     ISO Abbreviation:  Endocrinology     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-08-24     Completed Date:  2012-10-29     Revised Date:  2013-09-03    
Medline Journal Info:
Nlm Unique ID:  0375040     Medline TA:  Endocrinology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  4568-79     Citation Subset:  AIM; IM    
Affiliation:
Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington 99352-9104, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Antioxidants / metabolism*
Decidua / metabolism*
Female
Mice
Oxidative Stress / genetics
Premature Birth / genetics,  metabolism
Tumor Suppressor Protein p53 / deficiency*,  genetics
Uterus / metabolism*
Grant Support
ID/Acronym/Agency:
5P41RR018522-10/RR/NCRR NIH HHS; 8 P41 GM103493-10/GM/NIGMS NIH HHS; HD068524/HD/NICHD NIH HHS; HD12304/HD/NICHD NIH HHS; P41 GM103493/GM/NIGMS NIH HHS; P41 RR018522/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Antioxidants; 0/Tumor Suppressor Protein p53
Comments/Corrections

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