| The Ustilago maydis Clp1 protein orchestrates pheromone and b-dependent signaling pathways to coordinate the cell cycle and pathogenic development. | |
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MedLine Citation:
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PMID: 20729384 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Regulation of the cell cycle and morphogenetic switching during pathogenic and sexual development in Ustilago maydis is orchestrated by a concerted action of the a and b mating-type loci. Activation of either mating-type locus triggers the G2 cell cycle arrest that is a prerequisite for the formation of the infectious dikaryon; this cell cycle arrest is released only after penetration of the host plant. Here, we show that bW, one of the two homeodomain transcription factors encoded by the b mating-type locus, and the zinc-finger transcription factor Rbf1, a master regulator for pathogenic development, interact with Clp1 (clampless 1), a protein required for the distribution of nuclei during cell division of the dikaryon. In addition, we identify Cib1, a previously undiscovered bZIP transcription factor required for pathogenic development, as a Clp1-interacting protein. Clp1 interaction with bW blocks b-dependent functions, such as the b-dependent G2 cell cycle arrest and dimorphic switching. The interaction of Clp1 with Rbf1 results in the repression of the a-dependent pheromone pathway, conjugation tube formation, and the a-induced G2 cell cycle arrest. The concerted interaction of Clp1 with Rbf1 and bW coordinates a- and b-dependent cell cycle control and ensures cell cycle release and progression at the onset of biotrophic development. |
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Authors:
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Kai Heimel; Mario Scherer; David Schuler; Jörg Kämper |
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Publication Detail:
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Type: Journal Article Date: 2010-08-20 |
Journal Detail:
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Title: The Plant cell Volume: 22 ISSN: 1532-298X ISO Abbreviation: Plant Cell Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-09-29 Completed Date: 2011-01-13 Revised Date: 2011-08-03 |
Medline Journal Info:
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Nlm Unique ID: 9208688 Medline TA: Plant Cell Country: United States |
Other Details:
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Languages: eng Pagination: 2908-22 Citation Subset: IM |
Affiliation:
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Department of Genetics, Karlsruhe Institute of Technology, 76187 Karlsruhe, Germany. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Cell Cycle* Cell Cycle Proteins / genetics, metabolism* DNA, Fungal / genetics Fungal Proteins / genetics, metabolism* Genes, Mating Type, Fungal Homeodomain Proteins Pheromones / physiology* Signal Transduction Transcription Factors / genetics, metabolism Ustilago / cytology*, genetics, pathogenicity |
| Chemical | |
Reg. No./Substance:
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0/BW1 protein, Ustilago maydis; 0/Cell Cycle Proteins; 0/DNA, Fungal; 0/Fungal Proteins; 0/Homeodomain Proteins; 0/Pheromones; 0/Transcription Factors |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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