Document Detail

Usnic acid and diffractaic acid as analgesic and antipyretic components of Usnea diffracta.
MedLine Citation:
PMID:  7753915     Owner:  NLM     Status:  MEDLINE    
Diffractaic acid and usnic acid were identified as the analgesic and antipyretic components of a lichen, Usnea diffracta. Both compounds showed an analgesic effect by the acetic acid-induced writhing and tail-pressure methods in mice. Regarding the effect on normal body temperature and LPS-induced hyperthermia in mice, diffractaic acid showed a significant effect only on the former and usnic acid only on the latter.
E Okuyama; K Umeyama; M Yamazaki; Y Kinoshita; Y Yamamoto
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Planta medica     Volume:  61     ISSN:  0032-0943     ISO Abbreviation:  Planta Med.     Publication Date:  1995 Apr 
Date Detail:
Created Date:  1995-06-21     Completed Date:  1995-06-21     Revised Date:  2000-12-18    
Medline Journal Info:
Nlm Unique ID:  0066751     Medline TA:  Planta Med     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  113-5     Citation Subset:  IM    
Faculty of Pharmaceutical Sciences, Chiba University, Japan.
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MeSH Terms
Analgesics / chemistry,  pharmacology*
Analgesics, Non-Narcotic / chemistry,  pharmacology*
Anisoles / chemistry,  pharmacology*
Benzofurans / chemistry,  pharmacology*
Chromatography, Thin Layer
Hydroxybenzoic Acids / chemistry,  pharmacology*
Magnetic Resonance Spectroscopy
Plants, Medicinal / chemistry*
Spectrophotometry, Infrared
Reg. No./Substance:
0/Analgesics; 0/Analgesics, Non-Narcotic; 0/Anisoles; 0/Benzofurans; 0/Hydroxybenzoic Acids; 125-46-2/usnic acid; 436-32-8/diffractaic acid

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