| Using a toroid transducer for thermal ablation by high-intensity-focused ultrasound increases the coagulated volume. | |
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MedLine Citation:
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PMID: 18529305 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Here, we report that a new design of High Intensity Focused Ultrasound transducer can significantly enlarge the coagulated volume over short periods of time, and that treatment in the liver can be guided in real-time using an integrated ultrasound imaging probe. Eight ultrasound emitters, divided into 256 elements, were created by sectioning a single toroid piezocomposite transducer. The focal zone was conical in shape and located 70 mm from the transducer; enabling the treatment of deep-seated tumors. A single thermal lesion was created when the eight emitters performed alternative and consecutive 5 s ultrasound exposures. This paper presents in vivo evidence that the coagulated volume obtained from a 40 s total exposure in the liver was 7.0+/-2.5 cm(3) (min 1.5 - max 20.0 cm(3)). All lesions were visible with high contrast on sonograms. The correlation between the diameter of lesions observed on sonograms and during gross examination was 92%. This method also allowed the user to easily enlarge the coagulated volume by juxtaposing single lesions. This approach may have a role in treating unresectable colorectal liver metastases and may also be used in conjunction with resection to extend its limits. |
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Authors:
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David Melodelima; William N'djin; Hubert Parmentier; Michel Rivoire; Jean Yves Chapelon |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of the Acoustical Society of America Volume: 123 ISSN: 1520-8524 ISO Abbreviation: J. Acoust. Soc. Am. Publication Date: 2008 May |
Date Detail:
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Created Date: 2008-06-05 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7503051 Medline TA: J Acoust Soc Am Country: United States |
Other Details:
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Languages: eng Pagination: 2995 Citation Subset: IM |
Affiliation:
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INSERM, U556, 151 Cours Albert Thomas, 69003 Lyon, France, melodelima@lyon.inserm.fr. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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