Document Detail

Using a spectral reflectance technique to measure transcutaneous bilirubin in neonates: a new device.
MedLine Citation:
PMID:  12141334     Owner:  HSR     Status:  MEDLINE    
Devices that use a spectral reflectance technique are used to non-invasively measure total bilirubin levels in neonates to monitor the development of hyperbilirubinemia. As a screening technique for the healthy neonate population, these devices provide instantaneous information, may reduce the need of heel-pricks on neonates, and indicate which neonates will need serum bilirubin measurement. Evidence from studies supported by the manufacturer of BiliChek (tm), the newest device using the spectral reflectance technique, suggests that there is a linear correlation between transcutaneous bilirubin measured by BiliChek (tm) and total serum bilirubin as measured by the gold standard technique (i.e. HPLC). The correlation, however, is limited by gestational age of the neonate, as well as certain pathological neonatal conditions. Prospective cohort studies on the effectiveness of the technology in the reduction of hospital readmission, and using the incidence of morbidity and mortality from kernicterus as clinical endpoints, would be useful.
Chuong Ho
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Issues in emerging health technologies     Volume:  -     ISSN:  1488-6316     ISO Abbreviation:  Issues Emerg Health Technol     Publication Date:  2002 Jul 
Date Detail:
Created Date:  2002-07-25     Completed Date:  2002-07-31     Revised Date:  2010-01-22    
Medline Journal Info:
Nlm Unique ID:  100886782     Medline TA:  Issues Emerg Health Technol     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  1-4     Citation Subset:  T    
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MeSH Terms
Bilirubin / blood*
Costs and Cost Analysis
Device Approval
Evidence-Based Medicine
Infant, Newborn
Jaundice, Neonatal / diagnosis*
Neonatal Screening / instrumentation*
Practice Guidelines as Topic
Sensitivity and Specificity
Skin / chemistry*
Spectrum Analysis / economics,  instrumentation,  methods*
United States
United States Food and Drug Administration
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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