Document Detail

Using the interrupter technique to evaluate airway resistance in cystic fibrosis patients.
MedLine Citation:
PMID:  22576426     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To measure airway resistance with the interrupter resistance (Rint) technique in patients with cystic fibrosis (CF) and to determine whether Rint values correlate with spirometric parameters, as well as to evaluate the accuracy of the Rint technique in determining the airway response to a bronchodilator.
METHODS: This was a cross-sectional study involving 38 children and adolescents with CF followed at the Cystic Fibrosis Outpatient Clinic of the São Lucas Hospital, located in the city of Porto Alegre, Brazil. After Rint had been measured, the subjects underwent spirometry. To evaluate bronchodilator response, we repeated the measurements after the use of inhaled albuterol.
RESULTS: There was a strong correlation between inverse Rint and FEV1 (r = 0.8; p < 0.001), and there was a moderate correlation between inverse Rint and FEF25-75% (r = 0.74; p < 0.001), as well as between inverse Rint and body mass index (r = 0.62; p < 0.001). We used a ROC curve to compare the bronchodilator response, as determined by Rint, with spirometric values. For a Rint cut-off point of -28%, the area under the curve was 0.75, with a sensitivity of 66% and a specificity of 82%.
CONCLUSIONS: Our findings suggest that Rint correlates well with spirometric parameters, although the Rint technique was not sufficiently accurate to replace spirometry in the evaluation of bronchodilator responses.
Alessandra Rocha; Márcio Vinicius Fagundes Donadio; Dariana Vale de Avila; Patricia Xavier Hommerding; Paulo José Cauduro Marostica
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Jornal brasileiro de pneumologia : publicaça̋o oficial da Sociedade Brasileira de Pneumologia e Tisilogia     Volume:  38     ISSN:  1806-3756     ISO Abbreviation:  J Bras Pneumol     Publication Date:    2012 Mar-Apr
Date Detail:
Created Date:  2012-05-11     Completed Date:  2012-11-30     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  101222274     Medline TA:  J Bras Pneumol     Country:  Brazil    
Other Details:
Languages:  eng; por     Pagination:  188-93     Citation Subset:  IM    
Programa de Pós-Graduação em Saúde da Criança e do Adolescente, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.
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MeSH Terms
Airway Resistance / drug effects*,  physiology
Albuterol / administration & dosage
Bronchodilator Agents / administration & dosage
Child, Preschool
Cross-Sectional Studies
Cystic Fibrosis / drug therapy,  physiopathology*
Respiratory Function Tests / methods*
Spirometry / methods*
Reg. No./Substance:
0/Bronchodilator Agents; 18559-94-9/Albuterol

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