Document Detail


Using immediate-early genes to map hippocampal subregional functions.
MedLine Citation:
PMID:  18007019     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Different functions have been suggested for the hippocampus and its subdivisions along both transversal and longitudinal axes. Expression of immediate-early genes (IEGs) has been used to map specific functions onto neuronal activity in different areas of the brain including the hippocampus (IEG imaging). Here we review IEG studies on hippocampal functional dissociations with a particular focus on the CA3 subregion. We first discuss the cellular functions of IEGs and the brain system interactions that govern their dynamic expression in hippocampal neurons to provide a more solid framework for interpreting the findings from IEG studies. We show the pitfalls and shortcomings of conventional IEG imaging studies and describe advanced methods using IEGs for imaging of neuronal activity or functional intervention. We review the current IEG evidence of hippocampal function, subregional-specific contribution to different stages of memory formation, systems consolidation, functional dissociation between memory and anxiety/behavioral inhibition along the septotemporal axis, and different neural network properties of hippocampal subregions. In total, IEG studies provide support for (1) the role of the hippocampus in spatial and contextual learning and memory, (2) its role in continuous encoding of ongoing experience, (3) septotemporal dissociations between memory and anxiety, and (4) a dynamic relationship between pattern separation and pattern completion in the CA3 subregion. In closing, we provide a framework for how cutting-edge IEG imaging and intervention techniques will likely contribute to better understanding of the specific functions of CA3 and other hippocampal subregions.
Authors:
Stepan Kubik; Teiko Miyashita; John F Guzowski
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2007-11-14
Journal Detail:
Title:  Learning & memory (Cold Spring Harbor, N.Y.)     Volume:  14     ISSN:  1549-5485     ISO Abbreviation:  Learn. Mem.     Publication Date:  2007 Nov 
Date Detail:
Created Date:  2007-11-16     Completed Date:  2008-01-17     Revised Date:  2008-07-03    
Medline Journal Info:
Nlm Unique ID:  9435678     Medline TA:  Learn Mem     Country:  United States    
Other Details:
Languages:  eng     Pagination:  758-70     Citation Subset:  IM    
Affiliation:
Department of Neurobiology and Behavior Center for the Neurobiology of Learning and Memory, University of California, Irvine, California 92697-3800, USA. stepan.k@uci.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Brain Mapping*
Genes, Immediate-Early / physiology*
Hippocampus / anatomy & histology,  physiology*
Humans
Memory / physiology*
Neuronal Plasticity / genetics*
Grant Support
ID/Acronym/Agency:
MH060123/MH/NIMH NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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