| Using hyaluronic acid derivatives and cultured autologous fibroblasts and keratinocytes in a lower limb wound in a patient with diabetes: a case report. | |
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MedLine Citation:
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PMID: 12271733 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Patients with diabetes have an impaired wound healing process that contributes to the pathophysiology that may lead to amputation. In this case study, an extensive (103.49 cm2) full-thickness cutaneous wound with exposure of a necrotic Achilles' tendon in a patient with diabetes, neuropathy, and infrapopliteal vascular disease of the lower limbs was healed using a two-stage autologous skin substitute technique. The scaffolds on which the autologous fibroblasts and keratinocytes were grown comprised an ester derivative of hyaluronic acid. Two applications of the cultured autologous fibroblasts and one of the cultured autologous keratinocytes were placed on the wound at 7-day intervals. The ulcer healed completely 60 days following the first fibroblast graft application. After 16 months of follow-up, no recurrence was noted and the patient can walk without ancillary support. This novel tissue engineering technique is a promising treatment for wound healing. |
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Authors:
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Luca Dalla Paola; Alberto Cogo; Walter Deanesi; Cristina Stocchiero; Valerie Carmela Colletta |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Ostomy/wound management Volume: 48 ISSN: 0889-5899 ISO Abbreviation: Ostomy Wound Manage Publication Date: 2002 Sep |
Date Detail:
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Created Date: 2002-09-25 Completed Date: 2002-10-08 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8912029 Medline TA: Ostomy Wound Manage Country: United States |
Other Details:
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Languages: eng Pagination: 46-9 Citation Subset: N |
Affiliation:
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Diabetic Foot Unit, Department of Endocrinology and Metabolism, Villa Berica Hospital, Vicenza, Italy. ldallapaola@libero.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Achilles Tendon
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injuries* Adjuvants, Immunologic / therapeutic use* Aged Cells, Cultured Diabetic Neuropathies / physiopathology* Fibroblasts* Humans Hyaluronic Acid / analogs & derivatives, therapeutic use* Keratinocytes* Male Treatment Outcome Wound Healing / drug effects* |
| Chemical | |
Reg. No./Substance:
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0/Adjuvants, Immunologic; 9004-61-9/Hyaluronic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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