Document Detail

Using experimental design to optimize the process parameters in fluidized bed granulation.
MedLine Citation:
PMID:  11247535     Owner:  NLM     Status:  MEDLINE    
In this study many parameters were screened for a small-scale granulation process for their effect on the yield of granules between 75 and 500 microns and the geometrical granule mean size (d50). First a Plackett-Burman design was applied to screen the inlet air temperature, the inlet flow rate, the spray rate, the nozzle air pressure, the nozzle spray diameter, and the nozzle position. The Plackett-Burman design showed that the key process parameters were the inlet flow rate and the spray rate and probably also the inlet air temperature. Afterward a fractional factorial design (2(5-2)) was applied to screen the remaining parameters plus the nozzle aircap position and the spraying time interval. The fractional factorial design showed that the nozzle air pressure was also important. As the target values for the granule yield (between 75 and 500 microns) and the geometric mean granule size (between 300 and 500 microns) were reached during the screening experiments, further optimization was not considered necessary.
B Rambali; L Baert; D Thoné; D L Massart
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Drug development and industrial pharmacy     Volume:  27     ISSN:  0363-9045     ISO Abbreviation:  Drug Dev Ind Pharm     Publication Date:  2001 Jan 
Date Detail:
Created Date:  2001-03-14     Completed Date:  2001-05-31     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7802620     Medline TA:  Drug Dev Ind Pharm     Country:  United States    
Other Details:
Languages:  eng     Pagination:  47-55     Citation Subset:  IM    
Farmaceutisch Instituut, Vrije Universiteit Brussel, Laarbeeklaan 103, B-1090 Brussels, Belgium.
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MeSH Terms
Air Movements
Equipment Design
Models, Theoretical
Research Design
Technology, Pharmaceutical*
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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