Document Detail

Using epidemiology to regulate food additives: saccharin case-control studies.
MedLine Citation:
PMID:  6431484     Owner:  NLM     Status:  MEDLINE    
The increasing use of nonnutritive sweeteners and the widely publicized 1969 ban on cyclamate led to additional investigations in rodents of the carcinogenic potential of saccharin. Preliminary results of a long-term feeding study indicated formation of bladder tumors in rodents, and collective experimental evidence has demonstrated that high doses of the synthetic sweetener saccharin can cause bladder cancer in rodents. Based on the results of that and other rodent studies indicating an increased risk of bladder cancer associated with saccharin, the Commissioner of the Food and Drug Administration announced the agency's intention to propose a ban on saccharin. This intention was made known in April 1977 under the Delaney Clause of the Food, Drug, and Cosmetic Act. The clause essentially states that no additive shall be deemed safe if it is found to induce cancer in man or animals, or if it is found, after tests appropriate for the evaluation of the safety of food additives, to induce cancer in man or animals. Also in 1977, a group of epidemiologists began to assess the available epidemiologic information to determine the potential human risk. This report describes the assessment of several human epidemiologic studies available then and the results of more recent epidemiologic studies.
F Cordle; S A Miller
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Public health reports (Washington, D.C. : 1974)     Volume:  99     ISSN:  0033-3549     ISO Abbreviation:  Public Health Rep     Publication Date:    1984 Jul-Aug
Date Detail:
Created Date:  1984-09-05     Completed Date:  1984-09-05     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  9716844     Medline TA:  Public Health Rep     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  365-9     Citation Subset:  AIM; IM    
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MeSH Terms
Epidemiologic Methods*
Food Additives*
Legislation, Drug
Saccharin / poisoning*
United States
United States Food and Drug Administration*
Urinary Bladder Neoplasms / etiology*
Reg. No./Substance:
0/Food Additives; 81-07-2/Saccharin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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