| Using a dual inlet atmospheric pressure ionization source as a dynamic reaction vessel. | |
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MedLine Citation:
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PMID: 21080504 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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Atmospheric pressure ionization (API) sources have the ability to serve as dynamic 'reaction vessels' and this capability has been rapidly evolving over the past few years. With API sources, many different reagents and source conditions can be rapidly explored with minimal carryover or contamination of the mass spectrometer. While most API applications involve the simple protonation/deprotonation of analyte molecules, a great deal of flexibility and utility is available in almost any API source, provided the reagents and ionization conditions are judiciously selected. Here, the generation of a unique and useful class of reagent ions at atmospheric pressure is demonstrated for the first time. Within the AP gas-phase environment of a dual inlet ion source, the gas-phase synthesis of substituted N-phenylpyridinium cations is demonstrated by establishing conditions favorable to the nucleophilic substitution reaction required for their formation. The flexibility of this API source as a reaction vessel is also demonstrated. |
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Authors:
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J Larry Campbell |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Rapid communications in mass spectrometry : RCM Volume: 24 ISSN: 1097-0231 ISO Abbreviation: Rapid Commun. Mass Spectrom. Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-11-16 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8802365 Medline TA: Rapid Commun Mass Spectrom Country: England |
Other Details:
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Languages: eng Pagination: 3527-30 Citation Subset: - |
Copyright Information:
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Copyright © 2010 John Wiley & Sons, Ltd. |
Affiliation:
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AB SCIEX, 71 Four Valley Drive, Concord, Ontario, Canada. larry.campbell@absciex.com |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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