Document Detail

Using corticosteroids during pregnancy. Are topical, inhaled, or systemic agents associated with risk?
MedLine Citation:
PMID:  15455804     Owner:  NLM     Status:  MEDLINE    
QUESTION: I am concerned about use of corticosteroids during pregnancy. Some of my women patients of reproductive age are using topical, inhaled, or oral preparations, and I am not sure what to advise.
ANSWER: Both topical and systemic corticosteroids are used for a variety of autoimmune and inflammatory conditions. Results of first-trimester studies were inconclusive and underpowered. Recent meta-analyses suggest a small but significant association between use of systemic corticosteroids during the first trimester and oral clefts. This is consistent with results of animal studies. No similar evidence exists for topical or inhaled corticosteroids, probably because of much lower systemic exposure.
D Oren; I Nulman; M Makhija; S Ito; Gideon Koren
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Canadian family physician Médecin de famille canadien     Volume:  50     ISSN:  0008-350X     ISO Abbreviation:  Can Fam Physician     Publication Date:  2004 Aug 
Date Detail:
Created Date:  2004-09-30     Completed Date:  2004-10-19     Revised Date:  2013-05-20    
Medline Journal Info:
Nlm Unique ID:  0120300     Medline TA:  Can Fam Physician     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  1083-5     Citation Subset:  IM    
Motherisk Team, Hospital for Sick Children, Toronto, Ont.
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MeSH Terms
Administration, Inhalation
Administration, Topical
Adrenal Cortex Hormones / administration & dosage,  adverse effects*,  therapeutic use
Infusions, Intravenous
Meta-Analysis as Topic
Mouth Abnormalities / chemically induced
Pregnancy Complications / etiology*,  prevention & control*
Pregnancy Trimester, First
Risk Assessment
Reg. No./Substance:
0/Adrenal Cortex Hormones

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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