| Using conditional mutagenesis to study the brain. | |
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MedLine Citation:
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PMID: 14643079 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Conditional genetic modifications are used to determine how individual molecules contribute to the function of defined neuronal circuits in the mouse brain. Among various techniques for these genetic modifications, the tetracycline transactivator and the Cre-loxP systems have proved to be most successful in recent years. Here we describe the basic principles, recent developments, and potential applications of these methodologies. We discuss their impact on the study of general brain function and their use for modeling different brain disorders. |
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Authors:
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Alexei Morozov; Christoph Kellendonk; Eleanor Simpson; Francois Tronche |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Biological psychiatry Volume: 54 ISSN: 0006-3223 ISO Abbreviation: Biol. Psychiatry Publication Date: 2003 Dec |
Date Detail:
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Created Date: 2003-12-03 Completed Date: 2004-02-04 Revised Date: 2006-08-24 |
Medline Journal Info:
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Nlm Unique ID: 0213264 Medline TA: Biol Psychiatry Country: United States |
Other Details:
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Languages: eng Pagination: 1125-33 Citation Subset: IM |
Affiliation:
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Unit on Behavioral Genetics, Laboratory of Molecular Pathophysiology, Department of Health and Humans Services (AM), National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Brain / metabolism* Gene Deletion Gene Expression Regulation Genetic Engineering Immunohistochemistry Integrases / genetics Learning Memory Mice Mice, Knockout Mice, Transgenic Mutagenesis* Neuronal Plasticity Tetracycline / metabolism Trans-Activators / genetics, metabolism Transcription, Genetic Viral Proteins / genetics |
| Chemical | |
Reg. No./Substance:
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0/Trans-Activators; 0/Viral Proteins; 60-54-8/Tetracycline; EC 2.7.7.-/Cre recombinase; EC 2.7.7.-/Integrases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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