Document Detail

Using conditional mutagenesis to study the brain.
MedLine Citation:
PMID:  14643079     Owner:  NLM     Status:  MEDLINE    
Conditional genetic modifications are used to determine how individual molecules contribute to the function of defined neuronal circuits in the mouse brain. Among various techniques for these genetic modifications, the tetracycline transactivator and the Cre-loxP systems have proved to be most successful in recent years. Here we describe the basic principles, recent developments, and potential applications of these methodologies. We discuss their impact on the study of general brain function and their use for modeling different brain disorders.
Alexei Morozov; Christoph Kellendonk; Eleanor Simpson; Francois Tronche
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Biological psychiatry     Volume:  54     ISSN:  0006-3223     ISO Abbreviation:  Biol. Psychiatry     Publication Date:  2003 Dec 
Date Detail:
Created Date:  2003-12-03     Completed Date:  2004-02-04     Revised Date:  2006-08-24    
Medline Journal Info:
Nlm Unique ID:  0213264     Medline TA:  Biol Psychiatry     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1125-33     Citation Subset:  IM    
Unit on Behavioral Genetics, Laboratory of Molecular Pathophysiology, Department of Health and Humans Services (AM), National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA.
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MeSH Terms
Brain / metabolism*
Gene Deletion
Gene Expression Regulation
Genetic Engineering
Integrases / genetics
Mice, Knockout
Mice, Transgenic
Neuronal Plasticity
Tetracycline / metabolism
Trans-Activators / genetics,  metabolism
Transcription, Genetic
Viral Proteins / genetics
Reg. No./Substance:
0/Trans-Activators; 0/Viral Proteins; 60-54-8/Tetracycline; EC 2.7.7.-/Cre recombinase; EC 2.7.7.-/Integrases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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