Document Detail

Using case-control studies to assess the prevention of inflicted traumatic brain injury.
MedLine Citation:
PMID:  18374267     Owner:  NLM     Status:  MEDLINE    
Because the incidence of inflicted traumatic brain injury (inflicted TBI) is low, even in populations at increased risk, very large samples are necessary to have adequate statistical power to conduct a randomized clinical trial of the effectiveness of a potential intervention to prevent inflicted TBI. This requirement for large samples, in addition to the logistic demands of prospective clinical trials, makes it prohibitively expensive to conduct such studies. Case-control studies provide a statistically efficient and logistically and economically feasible alternative approach to evaluating such interventions. However, because these are observational studies, they are susceptible to bias. Approaches are presented to conducting and analyzing case-control studies to evaluate interventions to prevent inflicted TBI while assessing and minimizing possible bias.
Eugene D Shapiro
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  American journal of preventive medicine     Volume:  34     ISSN:  0749-3797     ISO Abbreviation:  Am J Prev Med     Publication Date:  2008 Apr 
Date Detail:
Created Date:  2008-03-31     Completed Date:  2008-07-02     Revised Date:  2014-05-01    
Medline Journal Info:
Nlm Unique ID:  8704773     Medline TA:  Am J Prev Med     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  S153-6     Citation Subset:  IM    
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MeSH Terms
Bias (Epidemiology)
Brain Injuries / prevention & control*
Case-Control Studies*
Child, Preschool
Program Evaluation* / methods
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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