| Using case-control studies to assess the prevention of inflicted traumatic brain injury. | |
MedLine Citation:
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PMID: 18374267 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Because the incidence of inflicted traumatic brain injury (inflicted TBI) is low, even in populations at increased risk, very large samples are necessary to have adequate statistical power to conduct a randomized clinical trial of the effectiveness of a potential intervention to prevent inflicted TBI. This requirement for large samples, in addition to the logistic demands of prospective clinical trials, makes it prohibitively expensive to conduct such studies. Case-control studies provide a statistically efficient and logistically and economically feasible alternative approach to evaluating such interventions. However, because these are observational studies, they are susceptible to bias. Approaches are presented to conducting and analyzing case-control studies to evaluate interventions to prevent inflicted TBI while assessing and minimizing possible bias. |
Authors:
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Eugene D Shapiro |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: American journal of preventive medicine Volume: 34 ISSN: 0749-3797 ISO Abbreviation: Am J Prev Med Publication Date: 2008 Apr |
Date Detail:
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Created Date: 2008-03-31 Completed Date: 2008-07-02 Revised Date: 2013-04-05 |
Medline Journal Info:
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Nlm Unique ID: 8704773 Medline TA: Am J Prev Med Country: Netherlands |
Other Details:
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Languages: eng Pagination: S153-6 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, Yale University School of Medicine, New Haven, Connecticut 06520-8064, USA. Eugene.Shapiro@yale.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Bias (Epidemiology) Brain Injuries / prevention & control* Case-Control Studies* Child, Preschool Humans Program Evaluation* / methods |
| Grant Support | |
ID/Acronym/Agency:
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K24 RR022477-07/RR/NCRR NIH HHS; KL2 RR024138/RR/NCRR NIH HHS; KL2 TR000140/TR/NCATS NIH HHS; RR022477/RR/NCRR NIH HHS; UL1 RR024139/RR/NCRR NIH HHS; UL1 RR024139/RR/NCRR NIH HHS; UL1 TR000142/TR/NCATS NIH HHS |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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