Document Detail


Using carcinogenic potency ranking to assign air contaminants to emission classes.
MedLine Citation:
PMID:  12473407     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Carcinogenic air contaminants are assigned to emission classes with different emission limits on the basis of their inhalation carcinogenic potency within the revised form of the German First General Administrative Regulation Pertaining to the Federal Emission Control Law (Technical Instructions on Air Quality Control-TA Luft). Accordingly, compounds with high carcinogenic potency are regulated more strictly than less potent substances. The data on carcinogenic properties are heterogeneous. Twenty-five substances or substance groups have been scrutinized and a procedure has been developed to rank these chemicals according to their carcinogenic potency. For 14 substances well-founded unit risk estimates were available to allow assignment of these air contaminants to emission classes. Unit risk estimates for bromoethane, 2-butanone oxime, and o-toluidine were derived using the ED(10)/LED(10) method based on animal studies. For several substances no qualified unit risk estimates or carcinogenicity studies were available to estimate carcinogenic potency after inhalation. Carcinogenic potency of these substances was approximated using two simple methods, T25 and CELmin.
Authors:
Ulrike Schuhmacher-Wolz; Rainer Konietzka; Klaus Schneider
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Regulatory toxicology and pharmacology : RTP     Volume:  36     ISSN:  0273-2300     ISO Abbreviation:  Regul. Toxicol. Pharmacol.     Publication Date:  2002 Dec 
Date Detail:
Created Date:  2002-12-10     Completed Date:  2003-05-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8214983     Medline TA:  Regul Toxicol Pharmacol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  221-33     Citation Subset:  IM    
Affiliation:
Research and Advisory Institute on Hazardous Substances (FoBiG), Werderring 16, D-79098 Freiburg, Germany. ulrike.schuhmacher@fobig.de
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MeSH Terms
Descriptor/Qualifier:
Air Pollutants / adverse effects*,  classification*
Carcinogens / adverse effects*,  classification*
Humans
Inhalation Exposure*
Risk Assessment
Chemical
Reg. No./Substance:
0/Air Pollutants; 0/Carcinogens

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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