Document Detail

Using caenorhabditis to explore the evolution of the germ line.
MedLine Citation:
PMID:  22872485     Owner:  NLM     Status:  In-Data-Review    
Germ cells share core attributes and homologous molecular components across animal phyla. Nevertheless, abrupt shifts in reproductive mode often occur that are mediated by the rapid evolution of germ cell properties. Studies of Caenorhabditis nematodes show how the otherwise conserved RNA-binding proteins (RBPs) that regulate germline development and differentiation can undergo surprisingly rapid functional evolution. This occurs even as the narrow biochemical tasks performed by the RBPs remain constant. The biological roles of germline RBPs are thus highly context-dependent, and the inference of archetypal roles from isolated models in different phyla may therefore be premature.
Eric S Haag; Qinwen Liu
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Advances in experimental medicine and biology     Volume:  757     ISSN:  0065-2598     ISO Abbreviation:  Adv. Exp. Med. Biol.     Publication Date:  2013  
Date Detail:
Created Date:  2012-08-08     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0121103     Medline TA:  Adv Exp Med Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  405-25     Citation Subset:  IM    
Department of Biology, University of Maryland, Building 144, College Park, MD, 20742, USA,
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