Document Detail


Using c-Fos immunocytochemistry to identify forebrain regions that may inhibit maternal behavior in rats.
MedLine Citation:
PMID:  10832795     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Evidence indicates there is a neural system that inhibits maternal behavior in virgin rats. It has been suggested that pregnancy hormones promote the onset of maternal behavior by reducing the behavioral influence of this system. The authors used c-Fos immunocytochemistry to identify brain regions more activated by pup exposure in nonmaternal rats than in maternal rats. Previous experiments indicated that some of these regions, such as the posterodorsal medial amygdala and several medial hypothalamic sites, inhibit maternal behavior. For others, such as the ventral lateral septum, dorsal premammillary nucleus, and principal bed nucleus of the stria terminalis, this is the first indication that they could also inhibit maternal responding. These regions have previously been implicated in promoting defensive behaviors, consistent with the finding that nonmaternal rats actively avoid pups. These findings suggest the existence of a neural circuit through which pup exposure could promote defensive responses in virgin rats, and how pregnancy hormones could reduce such activity to stimulate maternal behavior.
Authors:
T P Sheehan; J Cirrito; M J Numan; M Numan
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Behavioral neuroscience     Volume:  114     ISSN:  0735-7044     ISO Abbreviation:  Behav. Neurosci.     Publication Date:  2000 Apr 
Date Detail:
Created Date:  2000-10-02     Completed Date:  2000-10-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8302411     Medline TA:  Behav Neurosci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  337-52     Citation Subset:  IM    
Affiliation:
Department of Psychology, Boston College, Massachusetts 02467, USA. sheehant@bc.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Brain Mapping
Female
Immunoenzyme Techniques
Maternal Behavior / physiology*
Nerve Net / physiology
Neural Inhibition / physiology*
Pregnancy
Prosencephalon / anatomy & histology,  physiology*
Proto-Oncogene Proteins c-fos / analysis*
Rats
Rats, Sprague-Dawley
Chemical
Reg. No./Substance:
0/Proto-Oncogene Proteins c-fos

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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