Document Detail

Using OKT3 to reverse cardiac allograft rejection.
MedLine Citation:
PMID:  2506149     Owner:  NLM     Status:  MEDLINE    
Acute rejection is the major impediment to long-term patient survival after organ transplantation. Historically, the treatment of cardiac allograft rejection has been use of cytotoxic agents combined with high-dose steroids, resulting in an increased incidence of undesirable side effects. A new agent, OKT3, appears to be capable of reversing acute rejection episodes without significant morbidity. We report 10 cardiac transplant recipients in whom acute rejection was dramatically reversed and clinical symptoms resolved after treatment with OKT3. Side effects were minimal, including febrile episodes, innocuous diarrheal syndromes, mild opportunistic infections, and one hypotensive episode. Critical care nurses administering OKT3 must be cognizant of the risks and benefits of therapy in addition to recognizing potential drug side effects. A nursing care plan was devised to identify nursing diagnoses and intervention related to patient and family education as well as recognition and treatment of the reported adverse effects.
K R Rogers; J T Sinnott; J E Ferguson
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Heart & lung : the journal of critical care     Volume:  18     ISSN:  0147-9563     ISO Abbreviation:  Heart Lung     Publication Date:  1989 Sep 
Date Detail:
Created Date:  1989-10-25     Completed Date:  1989-10-25     Revised Date:  2006-08-28    
Medline Journal Info:
Nlm Unique ID:  0330057     Medline TA:  Heart Lung     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  490-6     Citation Subset:  AIM; IM    
Cardiac Transplant Services, Tampa General Hospital, FL 33601.
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MeSH Terms
Acute Disease
Antibodies, Monoclonal / adverse effects,  therapeutic use*
Graft Rejection*
Heart Transplantation*
Middle Aged
Nursing Care
Nursing Diagnosis
Reg. No./Substance:
0/Antibodies, Monoclonal; 0/Muromonab-CD3

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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