| Using magnetic resonance angiography to measure abnormal synovial blood vessels in early inflammatory arthritis: a new imaging biomarker? | |
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MedLine Citation:
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PMID: 20360190 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To ascertain whether magnetic resonance angiography (MRA) can reliably detect synovial neovascularization in subjects with early inflammatory arthritis. METHODS: Subjects with 6 weeks to 6 months of clinical evidence of inflammatory hand arthritis had a radiograph, power Doppler ultrasound (PDU) scan, magnetic resonance imaging (MRI), and contrast enhanced MRA performed on the more symptomatic hand. Ultrasound examination of the wrist and 2nd-5th metacarpophalangeal (MCP) joints was scored for erosions, synovial thickening, and synovial blood flow. MRI were assessed using the OMERACT Rheumatoid Arthritis MRI Score (RAMRIS). MRA was used to assess the number of abnormal vessels in the 2nd-5th MCP and in the wrist. RESULTS: Of 30 subjects, 66.7% showed abnormal vasculature on MRA in the MCP and/or wrist; mean number of abnormal vessels was 5.24 (range 0-22). Number of abnormal vessels on MRA was strongly correlated with degree of blood flow seen in the corresponding area on PDU (r = 0.79, p <or= 0.0001). The number of abnormal vessels was highly correlated with MRI MCP synovitis scores (r = 0.69, p <or= 0.0001), MRI wrist synovitis scores (r = 0.73, p <or= 0.0001), and ultrasound synovitis scores (r = 0.68, p <or= 0.0001). CONCLUSION: In this cross-sectional pilot study, MRA identified abnormal vessels in patients with early inflammatory arthritis. This is the first report of MRA visualizing abnormal vessels in this patient population. If the degree of neovascularization in early inflammatory arthritis predicts disease course, MRA evidence of abnormal vessels could be a new imaging biomarker. |
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Authors:
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Lisa C Vasanth; Li Foong Foo; Hollis G Potter; Ronald S Adler; Kathleen C Finzel; Helene Pavlov; Lisa A Mandl |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2010-04-01 |
Journal Detail:
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Title: The Journal of rheumatology Volume: 37 ISSN: 0315-162X ISO Abbreviation: J. Rheumatol. Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-06-02 Completed Date: 2010-07-08 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7501984 Medline TA: J Rheumatol Country: Canada |
Other Details:
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Languages: eng Pagination: 1129-35 Citation Subset: IM |
Affiliation:
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Division of Rheumatology and Division of Radiology and Imaging, Hospital for Special Surgery, 535 East 70th Street, New York, NY 10021, USA. vasanthl@hss.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Arthritis / diagnosis*, physiopathology, radiography Biological Markers Blood Flow Velocity Blood Vessels / pathology*, physiopathology Cross-Sectional Studies Female Health Status Humans Magnetic Resonance Angiography / methods* Male Metacarpophalangeal Joint / pathology, ultrasonography Pilot Projects Prognosis Questionnaires Synovial Membrane / blood supply, pathology*, radiography Synovitis / pathology*, physiopathology, radiography Ultrasonography, Doppler Wrist Joint / pathology, ultrasonography |
| Grant Support | |
ID/Acronym/Agency:
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K23 AR050607-01/AR/NIAMS NIH HHS; M01 RR00047/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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