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Using Frozen Section to Identify Histologic Patterns in Stage I Lung Adenocarcinoma ≤ 3 cm: Accuracy and Interobserver Agreement.
MedLine Citation:
PMID:  24889415     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
AIMS: The IASLC/ATS/ERS classification of lung adenocarcinoma provides a prognostically significant histologic subclassification. The aim of this study is to investigate the accuracy, limitations, and interobserver agreement of frozen sections (FS) for predicting histologic subtype.
METHODS AND RESULTS: FS and permanent section slides from 361 resected stage I lung adenocarcinomas ≤ 3 cm were reviewed for predominant histologic subtype and presence or absence of lepidic, acinar, papillary, micropapillary, and solid patterns. Fifty cases were additionally reviewed by 3 pathologists to determine interobserver agreement. To test the accuracy of FS in judging degree of invasion, 5 pathologists reviewed FS slides from 35 cases with predominantly lepidic pattern. There was moderate agreement on predominant histologic subtype between FS and final diagnosis (κ = 0.565). FS had high specificity for micropapillary and solid patterns (94% and 96%, respectively), but sensitivity was low (37% and 69%, respectively). The interobserver agreement was satisfactory (κ > 0.6, except for acinar pattern).
CONCLUSIONS: FS can provide information on the presence of aggressive histologic patterns - micropapillary and solid - with high specificity but low sensitivity. It was difficult to predict the predominant pattern based on frozen section mostly due to sampling issues. This article is protected by copyright. All rights reserved.
Authors:
Yi-Chen Yeh; Jun-Ichi Nitadori; Kyuichi Kadota; Akihiko Yoshizawa; Natasha Rekhtman; Andre L Moreira; Camelia S Sima; Valerie W Rusch; Prasad S Adusumilli; William D Travis
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-5-29
Journal Detail:
Title:  Histopathology     Volume:  -     ISSN:  1365-2559     ISO Abbreviation:  Histopathology     Publication Date:  2014 May 
Date Detail:
Created Date:  2014-6-3     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7704136     Medline TA:  Histopathology     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
This article is protected by copyright. All rights reserved.
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