Document Detail

Using 17 α-hydroxyprogesterone caproate to impact rates of recurrent preterm delivery in clinical practice.
MedLine Citation:
PMID:  20170407     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Evaluation of an outpatient 17 α-hydroxyprogesterone caproate (17P) administration programme.
METHODS: A retrospective analysis of data collected from patients with a history of preterm birth (PTB) and current singleton gestation enrolled between 16.0 and 20.9 weeks' gestational age (GA) for weekly outpatient 17P administration and nursing assessment between 7/2004 and 12/2007 was conducted (n=3139).
RESULTS: The population was mostly white (50.3%), 18-35 years old (77.7%), and married (67.0%). Median GA at 17P initiation and stop was 17.4 (16.0, 20.9) weeks and 35.1 (18.6, 37.4) weeks. Mean injections per patient were 16.5±4.9, at an interval of 7.2 days. Median GA at delivery was 37.3 (18.6, 44.0) weeks. Rate of recurrent spontaneous PTB was 29.8%, with 15.5% and 7.0% with PTB at <35 and <32 weeks.
CONCLUSIONS: This represents the largest cohort reported to date of patients prescribed 17P therapy in clinical practice to prevent recurrent spontaneous PTB.
Andrei Rebarber; Nathan S Fox; Chad K Klauser; Niki B Istwan; Debbie J Rhea; Gary J Stanziano; Daniel H Saltzman
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians     Volume:  23     ISSN:  1476-4954     ISO Abbreviation:  J. Matern. Fetal. Neonatal. Med.     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-09-13     Completed Date:  2011-01-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101136916     Medline TA:  J Matern Fetal Neonatal Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  1139-42     Citation Subset:  IM    
Maternal Fetal Medicine Associates, New York, NY 10029, USA.
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MeSH Terms
Cohort Studies
Home Care Services*
Hydroxyprogesterones / administration & dosage*
Injections, Intramuscular
Obstetric Labor, Premature / drug therapy*
Patient Education as Topic
Patient Satisfaction
Premature Birth / prevention & control*
Prenatal Care
Progestins / administration & dosage*
Young Adult
Reg. No./Substance:
0/Hydroxyprogesterones; 0/Progestins; 630-56-8/17-alpha-hydroxy-progesterone caproate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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