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Using [1-(13) C]lactic acid for hyperpolarized (13) C MR cardiac studies.
MedLine Citation:
PMID:  25046652     Owner:  NLM     Status:  Publisher    
PURPOSE: Hyperpolarized [1-(13) C]lactate in solution may be a clinically relevant and safe substrate for real time MR investigations of key metabolic pathways. The potential of using hyperpolarized [1-(13) C]lactate for magnetic resonance studies of cardiac metabolism in vivo was explored.
METHODS: Neat [1-(13) C]lactic acid was hyperpolarized using the dynamic nuclear polarization process. Cardiac MR spectroscopy experiments were performed in vivo using hyperpolarized [1-(13) C]lactate and [1-(13) C]pyruvate in solutions.
RESULTS: A high degree of polarization was achieved for [1-(13) C]lactate in solution (16.7%). (13) C-bicarbonate was observed in rat hearts in vivo after either hyperpolarized [1-(13) C]lactate or hyperpolarized [1-(13) C]pyruvate was infused, but lower (13) C-bicarbonate to substrate ratio was observed with hyperpolarized [1-(13) C]lactate infusions. The response of (13) C-bicarbonate signal as a function of hyperpolarized [1-(13) C]lactate doses was also investigated and a saturation of (13) C-bicarbonate signal was observed at the highest dose of [1-(13) C]lactate used (0.69 mmol/kg).
CONCLUSION: This study demonstrated that the use of neat [1-(13) C]lactic acid as the DNP sample is a potential alternative to [1-(13) C]pyruvic acid for cardiac hyperpolarized (13) C MR studies. Hyperpolarized [1-(13) C]lactate may enable noninvasive assessment of cardiac PDH flux in cardiac patients in the near future. Magn Reson Med, 2014. © 2014 Wiley Periodicals, Inc.
Albert P Chen; Justin Y C Lau; Rohan D A Alvares; Charles H Cunningham
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-7-9
Journal Detail:
Title:  Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine     Volume:  -     ISSN:  1522-2594     ISO Abbreviation:  Magn Reson Med     Publication Date:  2014 Jul 
Date Detail:
Created Date:  2014-7-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8505245     Medline TA:  Magn Reson Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2014 Wiley Periodicals, Inc.
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