| Usefulness of the whole-blood interferon-gamma release assay for diagnosis of extrapulmonary tuberculosis. | |
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MedLine Citation:
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PMID: 19070449 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The whole-blood interferon-gamma enzyme-linked immunosorbent assay (QuantiFERON-TB Gold [QFT-G]; Cellestis, Carnegie, Australia) has been studied mainly for diagnosing active pulmonary tuberculosis (TB) or latent TB. We prospectively evaluated its diagnostic usefulness in patients suspected with extrapulmonary TB (EP-TB). Of the 100 adult patients with suspected EP-TB, 43 were classified as "confirmed" EP-TB and 5 as "probable" EP-TB. Of the 48 with EP-TB, 27 (56%) were diagnosed with TB lymphadenitis and 11 (17%) with skeletal TB. The overall sensitivity and specificity of the assay were 69% (95% confidence interval [CI(95)], 53-81%) and 82% (CI(95), 69-91%), respectively. Among 44 patients presented with cervical lymphadenopathy, the QFT-G assay showed 86% (CI(95), 64-97%) sensitivity and 87% (CI(95), 66-97%) specificity, whereas in 28 with skeletal involvement, the sensitivity and specificity of the assay were 45% (CI(95), 17-77%) and 81% (CI(95), 54-96%), respectively. These suboptimal diagnostic performances suggest that the QFT-G assay alone is not sufficient for the diagnosis of EP-TB. |
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Authors:
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Kyoung-Ho Song; Jae Hyun Jeon; Wan Beom Park; Sung-Han Kim; Kyoung Un Park; Nam Joong Kim; Myoung-don Oh; Hong Bin Kim; Kang Won Choe |
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Publication Detail:
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Type: Journal Article Date: 2008-12-12 |
Journal Detail:
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Title: Diagnostic microbiology and infectious disease Volume: 63 ISSN: 1879-0070 ISO Abbreviation: Diagn. Microbiol. Infect. Dis. Publication Date: 2009 Feb |
Date Detail:
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Created Date: 2009-01-19 Completed Date: 2009-08-07 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8305899 Medline TA: Diagn Microbiol Infect Dis Country: United States |
Other Details:
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Languages: eng Pagination: 182-7 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Aged, 80 and over Enzyme-Linked Immunosorbent Assay / methods* Female Humans Interferon-gamma / blood* Male Middle Aged Mycobacterium tuberculosis / genetics, isolation & purification Polymerase Chain Reaction Predictive Value of Tests Reagent Kits, Diagnostic Sensitivity and Specificity Tuberculosis / diagnosis*, immunology*, microbiology Tuberculosis, Lymph Node / diagnosis, immunology, microbiology |
| Chemical | |
Reg. No./Substance:
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0/Reagent Kits, Diagnostic; 82115-62-6/Interferon-gamma |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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