Document Detail


Usefulness of visual evaluation of the anterior thalamic radiation by diffusion tensor tractography for differentiating between Alzheimer's disease and elderly major depressive disorder patients.
MedLine Citation:
PMID:  23589698     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
BACKGROUND AND OBJECTIVE: Many surveys of neural integrity of the cerebral white matter with psychiatric diseases on diffusion tensor imaging have recently been performed, but these mainly utilize fractional anisotropy (FA) and the apparent diffusion coefficient (ADC) values, and the results were inconsistent and not fully applied clinically. In this study, we investigated the possibility of differentiating between Alzheimer's disease (AD) and elderly major depressive disorder (MDD) patients in whom early-stage symptoms are difficult to diagnose, by visually evaluating cerebral nerve fascicles utilizing diffusion tensor tractography. We also measured and evaluated FA and ADC values at the same time.
SUBJECTS AND METHODS: The subjects included 13 AD patients (age: 69.5 ± 5.1 years), 19 MDD patients (65.8 ± 5.7 years), and 22 healthy control (HC) subjects (67.4 ± 4.8 years). Images were acquired using a 1.5T magnetic resonance imaging device and analyzed by diffusion tensor tractography analysis software.
RESULTS: Depiction of the anterior thalamic radiation (ATR) tended to be poor in AD patients unlike in MDD patients and HC subjects. The FA values in the left superior longitudinal fasciculus and fornix (FX) in AD patients were significantly different from those in MDD patients and HC subjects. The ADC values in the bilateral ATR and left superior and inferior longitudinal fasciculi, left inferior fronto-occipital fasciculus, and FX in AD patients were significantly different from those in MDD patients and HC subjects.
CONCLUSION: Visual evaluation of the ATR in combination with the FA values of the left superior longitudinal fasciculus and FX and ADC values of the bilateral ATR, left superior and inferior longitudinal fasciculi, left inferior fronto-occipital fasciculus, and FX is useful for differentiating between AD and MDD patients, which further suggests that it may become a useful auxiliary diagnostic tool.
Authors:
Akira Niida; Richi Niida; Kazumasa Kuniyoshi; Makoto Motomura; Akihiko Uechi
Related Documents :
23870018 - Motor function after stereotactic radiosurgery for brain metastases in the region of th...
25095888 - Prevalence and prediction of coronary artery disease in patients with liver cirrhosis: ...
24731518 - Chrnb3 c.-57a>g functional promoter change affects parkinson's disease and smoking.
24314818 - Role of endoscopic treatment of vesico-ureteric reflux in downgrading renin angiotensin...
24148608 - Types of stroke recurrence in patients with ischemic stroke: a substudy from the profes...
15899048 - Increased serum ho-1 in hemophagocytic syndrome and adult-onset still's disease: use in...
Publication Detail:
Type:  Journal Article     Date:  2013-04-04
Journal Detail:
Title:  International journal of general medicine     Volume:  6     ISSN:  1178-7074     ISO Abbreviation:  Int J Gen Med     Publication Date:  2013  
Date Detail:
Created Date:  2013-04-16     Completed Date:  2013-04-17     Revised Date:  2013-04-19    
Medline Journal Info:
Nlm Unique ID:  101515487     Medline TA:  Int J Gen Med     Country:  New Zealand    
Other Details:
Languages:  eng     Pagination:  189-200     Citation Subset:  -    
Affiliation:
Department of Radiology, Nanbu Hospital, Itoman City, Okinawa, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Update of research on the role of EZH2 in cancer progression.
Next Document:  Hospital-based incidence of maternal heart failure during pregnancy in Nigeria.