Document Detail

Usefulness of various MRI sequences in the diagnosis of viral encephalitis.
MedLine Citation:
PMID:  20816658     Owner:  NLM     Status:  MEDLINE    
There is paucity of studies regarding the utility of various conventional MRI sequences in the diagnosis of viral encephalitis. The present study evaluates the usefulness of various MRI sequences in acute viral encephalitis. 88 consecutive viral encephalitis patients, aged 2-72 years were subjected to clinical evaluation. Consciousness was assessed by Glasgow Coma Scale (GCS). Serum or cerebrospinal fluid (CSF) was analyzed for dengue, Japanese encephalitis (JE), herpes, measles, echo, coxsackie and polio viruses using ELISA or PCR. Cranial MRI was done and T1, T2, FLAIR and DW images were obtained. The MRI changes were correlated with type of encephalitis and duration of illness. All the patients had altered sensorium and 37 had seizures. 22 patients had JE, 9 had dengue, 8 had herpes simplex encephalitis (HSE), 2 had Epstein-Barr virus encephalitis (EBVE) and 47 had non-specific encephalitis. The median duration of MRI study from onset was 10 days. In JE (20/22), HSE (8/8), and EBVE (2/2), MRI abnormalities were more common compared to dengue (2/9) and non-specific (20/47) encephalitis. The MRI abnormalities were more common in FLAIR (57.1%) compared to T2 (52.9%), DWI (38.1%) and T1 (19.3%) sequences. The mean ADC value in JE patients was lower (974.0±110.85×10⁻⁶ mm²/s) than HSE (1024.33±485.76×10⁻⁶ mm²/s). Additional MRI lesions were seen in 12.6% cases on FLAIR sequence. FLAIR and T2 sequences were more sensitive in revealing abnormalities in viral encephalitis.
U K Misra; J Kalita; R V Phadke; V Wadwekar; D K Boruah; A Srivastava; P K Maurya; A Bhattacharyya
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-09-09
Journal Detail:
Title:  Acta tropica     Volume:  116     ISSN:  1873-6254     ISO Abbreviation:  Acta Trop.     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-10-12     Completed Date:  2011-01-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370374     Medline TA:  Acta Trop     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  206-11     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier B.V. All rights reserved.
Department of Neurology, Sanjay Gandhi PGIMS, Lucknow, India.
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MeSH Terms
Cerebrospinal Fluid / virology
Child, Preschool
Consciousness Disorders
Encephalitis, Viral / diagnosis*,  pathology*,  physiopathology
Enzyme-Linked Immunosorbent Assay
Head / pathology,  radiography*
Magnetic Resonance Imaging / methods*
Middle Aged
Polymerase Chain Reaction
Severity of Illness Index
Viruses / isolation & purification
Young Adult

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