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Usefulness of tissue transglutaminase type 2 antibodies in early pregnancy.
MedLine Citation:
PMID:  22537115     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Celiac disease (CD), an autoimmune disease triggered by dietary gluten, is a multi-systemic disorder that primarily results in mucosal damage of the small intestine. Reproductive disorders and pregnancy complications have been associated with CD. Conflicting results have been published concerning CD and the risk of impaired fetal growth with reduced birthweight. The aim of our multicentric, perspective, case-control study was to determine the prevalence of undiagnosed CD in mothers of small for gestational age (SGA) newborns in two regions of Italy. The study included 480 mothers: group A consisted of 284 SGA newborns' mothers and group B consisted of 196 appropriate for gestational age (AGA) newborns' mothers. Tissue transglutaminase type 2 antibodies (TG2) IgA and IgG were measured in blood samples. We diagnosed two new cases of CD in asymptomatic mothers. It may be appropriate to include the TG2 to the panel of prenatal blood test.
Authors:
Maria Elisabetta Baldassarre; Annamaria Laneve; Antonietta Fontana; Fabio Manca; Gennaro Salvia; Patrizia Barcaglioni; Adolfo Cella; Silvia Giannuzzo; Luigi Esposito; Teresa Capursi; Carla Mastrorilli; Alexander Padovano; Nicola Laforgia
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-4-26
Journal Detail:
Title:  Immunopharmacology and immunotoxicology     Volume:  -     ISSN:  1532-2513     ISO Abbreviation:  -     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-4-27     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8800150     Medline TA:  Immunopharmacol Immunotoxicol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Gynecology, Obstetrics and Neonatology, Section of Neonatology and NICU, University of Bari , Bari , Italy.
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