| Usefulness of thyrotropin (TSH)-releasing hormone test and nocturnal surge of TSH for diagnosis of isolated deficit of TSH secretion. | |
MedLine Citation:
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PMID: 11238485 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Six patients with idiopathic isolated deficit of TSH secretion were examined and reported on. Their clinical symptoms and routine biochemical data were unclear and were not specific for hypothyroidism. Serum triiodothyronine, free thyroxine and TSH levels were slightly low or low-normal. Basal metabolic rate and thyroidal (123)I-uptake were also slightly low or low-normal. The response of serum TSH to TRH stimulation was blunted in all patients. No nocturnal surge of serum TSH level could be seen in any of the patients. Empty sella was revealed in three patients, and pituitary microadenoma in one patient via magnetic resolution imaging. Antihuman pituitary cytosol antibody was seen in five patients. Autoimmunity may have played a role in the pathogenesis of idiopathic isolated TSH deficiency. Routine examination of thyroid function cannot easily detect this disease. TSH response to TRH stimulation and nocturnal surge of TSH should be examined when this disease is suspected. |
Authors:
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N Yamakita; T Komaki; T Takao; T Murai; K Hashimoto; K Yasuda |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of clinical endocrinology and metabolism Volume: 86 ISSN: 0021-972X ISO Abbreviation: J. Clin. Endocrinol. Metab. Publication Date: 2001 Mar |
Date Detail:
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Created Date: 2001-03-12 Completed Date: 2001-04-05 Revised Date: 2005-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0375362 Medline TA: J Clin Endocrinol Metab Country: United States |
Other Details:
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Languages: eng Pagination: 1054-60 Citation Subset: AIM; IM |
Affiliation:
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Department of Internal Medicine, Matsunami General Hospital, Kasamatsu, Gifu-Prefecture 5016062, Japan. nyamakita@matsunami-hsp.or.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Autoantibodies / blood Autoimmunity Circadian Rhythm* Cytosol / immunology Female Humans Iodide Peroxidase / immunology Iodine Radioisotopes / metabolism Male Middle Aged Pituitary Gland / immunology, ultrastructure Pituitary Neoplasms / diagnosis, physiopathology Thyroglobulin / immunology Thyroid Gland / metabolism Thyrotropin / blood, deficiency*, secretion* Thyrotropin-Releasing Hormone / diagnostic use* Thyroxine / blood Triiodothyronine / blood |
| Chemical | |
Reg. No./Substance:
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0/Autoantibodies; 0/Iodine Radioisotopes; 24305-27-9/Thyrotropin-Releasing Hormone; 6893-02-3/Triiodothyronine; 7488-70-2/Thyroxine; 9002-71-5/Thyrotropin; 9010-34-8/Thyroglobulin; EC 1.11.1.8/Iodide Peroxidase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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