Document Detail

Usefulness of thyrotropin (TSH)-releasing hormone test and nocturnal surge of TSH for diagnosis of isolated deficit of TSH secretion.
MedLine Citation:
PMID:  11238485     Owner:  NLM     Status:  MEDLINE    
Six patients with idiopathic isolated deficit of TSH secretion were examined and reported on. Their clinical symptoms and routine biochemical data were unclear and were not specific for hypothyroidism. Serum triiodothyronine, free thyroxine and TSH levels were slightly low or low-normal. Basal metabolic rate and thyroidal (123)I-uptake were also slightly low or low-normal. The response of serum TSH to TRH stimulation was blunted in all patients. No nocturnal surge of serum TSH level could be seen in any of the patients. Empty sella was revealed in three patients, and pituitary microadenoma in one patient via magnetic resolution imaging. Antihuman pituitary cytosol antibody was seen in five patients. Autoimmunity may have played a role in the pathogenesis of idiopathic isolated TSH deficiency. Routine examination of thyroid function cannot easily detect this disease. TSH response to TRH stimulation and nocturnal surge of TSH should be examined when this disease is suspected.
N Yamakita; T Komaki; T Takao; T Murai; K Hashimoto; K Yasuda
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of clinical endocrinology and metabolism     Volume:  86     ISSN:  0021-972X     ISO Abbreviation:  J. Clin. Endocrinol. Metab.     Publication Date:  2001 Mar 
Date Detail:
Created Date:  2001-03-12     Completed Date:  2001-04-05     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  0375362     Medline TA:  J Clin Endocrinol Metab     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1054-60     Citation Subset:  AIM; IM    
Department of Internal Medicine, Matsunami General Hospital, Kasamatsu, Gifu-Prefecture 5016062, Japan.
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MeSH Terms
Autoantibodies / blood
Circadian Rhythm*
Cytosol / immunology
Iodide Peroxidase / immunology
Iodine Radioisotopes / metabolism
Middle Aged
Pituitary Gland / immunology,  ultrastructure
Pituitary Neoplasms / diagnosis,  physiopathology
Thyroglobulin / immunology
Thyroid Gland / metabolism
Thyrotropin / blood,  deficiency*,  secretion*
Thyrotropin-Releasing Hormone / diagnostic use*
Thyroxine / blood
Triiodothyronine / blood
Reg. No./Substance:
0/Autoantibodies; 0/Iodine Radioisotopes; 24305-27-9/Thyrotropin-Releasing Hormone; 6893-02-3/Triiodothyronine; 7488-70-2/Thyroxine; 9002-71-5/Thyrotropin; 9010-34-8/Thyroglobulin; EC Peroxidase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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