Document Detail


Usefulness of terminal deoxynucleotidyl transferase as prognosticator in leukemia patients.
MedLine Citation:
PMID:  8366299     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Peripheral blood samples from 55 previously untreated leukemia patients (33 males, 22 females) were analysed for terminal deoxynucleotidyl transferase (TdT) activity. TdT was significantly higher in patients with acute myelogenous leukemia (AML; P < 0.001), chronic myelogenous leukemia (CML; P < 0.05) and acute lymphoblastic leukemia (ALL; P < 0.001) when compared with controls. One patient with chronic lymphocytic leukemia (CLL) had undetectable TdT. Among leukemic patients, ALL patients had higher concentration of TdT than CML and AML patients. Females had higher TdT activity than males, although the difference between the two groups was not statistically significant. 68% TdT+ and 32% TdT- patients were in blastic crisis. Patients with more than 10% of blasts in the circulation had significantly higher TdT than blast-negative patients (P < 0.001). No difference in survival was observed between TdT+ and TdT- group. From these results, we conclude that the absolute TdT concentration is of little prognostic value in leukemia patients.
Authors:
J M Bhatavdekar; S N Trivedi; H H Vora; S N Shukla
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The International journal of biological markers     Volume:  8     ISSN:  0393-6155     ISO Abbreviation:  Int. J. Biol. Markers     Publication Date:    1993 Apr-Jun
Date Detail:
Created Date:  1993-10-06     Completed Date:  1993-10-06     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8712411     Medline TA:  Int J Biol Markers     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  77-80     Citation Subset:  IM    
Affiliation:
Division of Research, Gujarat Cancer Society, Asarwa, Ahmedabad, India.
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MeSH Terms
Descriptor/Qualifier:
DNA Nucleotidylexotransferase / blood*
Female
Humans
Leukemia / diagnosis,  enzymology*
Leukemia, Myelogenous, Chronic, BCR-ABL Positive / enzymology
Leukemia, Myeloid, Acute / enzymology
Leukocytes, Mononuclear / enzymology
Male
Precursor Cell Lymphoblastic Leukemia-Lymphoma / enzymology
Prognosis
Tumor Markers, Biological / blood
Chemical
Reg. No./Substance:
0/Tumor Markers, Biological; EC 2.7.7.31/DNA Nucleotidylexotransferase

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