Document Detail


Usefulness of six non-proprietary indirect markers of liver fibrosis in patients with chronic hepatitis C.
MedLine Citation:
PMID:  18324909     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: The aim of the study was to perform a comprehensive diagnostic evaluation of six popular, non-proprietary, indirect markers of liver fibrosis in a cohort of patients with chronic hepatitis C representing the full spectrum of disease severity. METHODS: A total of 167 consecutive, hepatitis C virus RNA positive, untreated patients with chronic hepatitis C were studied. Liver biopsy with histological evaluation and age/platelet index, aspartate aminotransferase/alanine aminotransferase ratio, aspartate aminotransferase to platelet ratio index, Bonacini's discriminant score, Forn's fibrosis index and FibroIndex were assessed in all patients. RESULTS: The area under the receiver operating characteristic curves of the six tests was always greater when performed to discriminate patients with METAVIR score F4 than when assessed to discriminate patients with METAVIR score > or =F2. At step-wise discriminant analysis the only indirect marker of fibrosis entered was FibroIndex, with the following correct classification of the patients: total=52.1, patients with scores F0-F1=62.2, patients with scores F2-F3=26.0 and patients with score F4=68.4. CONCLUSIONS: The ability to correctly classify patients using a panel of non-proprietary indirect markers of liver fibrosis is far from being ideal. Among them, FibroIndex appears to possess the best discriminating capacity. The simultaneous use of several indirect markers of liver fibrosis does not improve their diagnostic accuracy.
Authors:
Carlo Fabris; Carlo Smirne; Pierluigi Toniutto; Cosimo Colletta; Rachele Rapetti; Rosalba Minisini; Edmondo Falleti; Monica Leutner; Mario Pirisi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical chemistry and laboratory medicine : CCLM / FESCC     Volume:  46     ISSN:  1434-6621     ISO Abbreviation:  Clin. Chem. Lab. Med.     Publication Date:  2008  
Date Detail:
Created Date:  2008-03-07     Completed Date:  2008-05-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9806306     Medline TA:  Clin Chem Lab Med     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  253-9     Citation Subset:  IM    
Affiliation:
DPMSC Medical Liver Transplantation Unit, University of Udine, Udine, Italy.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Biological Markers / blood*
Biopsy
Female
Hepatitis C, Chronic / blood*,  pathology
Humans
Liver Cirrhosis / blood*,  diagnosis,  pathology
Male
Middle Aged
ROC Curve
Chemical
Reg. No./Substance:
0/Biological Markers

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