| Usefulness of serum transferrin receptor and serum ferritin in diagnosis of iron deficiency in infancy. | |
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MedLine Citation:
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PMID: 11063448 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The serum transferrin receptor (TfR) and the ratio of TfR to serum ferritin (TfR:SF) have been shown to be useful as early indicators of iron deficiency. OBJECTIVE: The objective of this study was to evaluate the performance of TfR and TfR:SF in the assessment of iron deficiency in infants and to analyze age-related changes in both variables. DESIGN: A total of 716 blood samples obtained from 515 healthy infants aged 8-15 mo were studied. RESULTS: In 144 samples in which all other laboratory indicators of iron status were within the reference range, the median and 95% CI for TfR and TfR:SF were 8.5 mg/L (95% CI: 5.9, 13.5) and 497 (95% CI: 134, 975), respectively. TfR and TfR:SF were significantly correlated with the other laboratory indicators of iron status. Furthermore, as the severity of iron deficiency progressed, there was a gradual increase in mean TfR concentration (P: < 0.00001; analysis of variance). The sensitivity of TfR > 13.5 mg/L and TfR:SF > 975 in the diagnosis of iron deficiency was 23.6% and 68.4%, respectively. The specificity was 98.3% and 63.3% for TfR and TfR:SF, respectively. The sensitivity and specificity of SF < 10 microg/L were 63.7% and 60.8%, respectively. Receiver operator characteristic analysis showed that TfR and TfR:SF were more accurate than was SF alone in the diagnosis of iron deficiency. CONCLUSIONS: TfR and TfR:SF showed age-related changes; TfR and TfR:SF appear to be better diagnostic tests for iron deficiency in infants than SF. |
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Authors:
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M Olivares; T Walter; J D Cook; E Hertrampf; F Pizarro |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The American journal of clinical nutrition Volume: 72 ISSN: 0002-9165 ISO Abbreviation: Am. J. Clin. Nutr. Publication Date: 2000 Nov |
Date Detail:
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Created Date: 2000-11-15 Completed Date: 2000-11-30 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0376027 Medline TA: Am J Clin Nutr Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1191-5 Citation Subset: AIM; IM |
Affiliation:
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Institute of Nutrition and Food Technology, University of Chile, Santiago, Chile. molivare@uec.inta.uchile.cl |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aging Erythrocyte Count Erythrocyte Indices Female Ferritins / blood* Hemoglobins / analysis Humans Infant Iron / deficiency* Male ROC Curve Receptors, Transferrin / blood* Reference Values Sensitivity and Specificity |
| Chemical | |
Reg. No./Substance:
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0/Hemoglobins; 0/Receptors, Transferrin; 7439-89-6/Iron; 9007-73-2/Ferritins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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