| Usefulness of serum lipid peroxide as a diagnostic test for hypoxic ischemic encephalopathy in the full-term neonate. | |
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MedLine Citation:
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PMID: 22481245 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Objective:To evaluate the usefulness of serum lipid peroxide (LPO) for hypoxic ischemic encephalopathy (HIE) in full-term neonates.Study Design:Diagnostic test evaluation forming three groups: (1) healthy full-term neonates (n=59), (2) at-risk full-term neonates without HIE (n=57) and (3) at-risk full-term neonates with HIE (n=57). HIE diagnosis was made using the Finer clinical classification at 48 h after birth. Serum LPO was taken at 4 h after birth and determined by spectrophotometry.Result:One hundred seventy-three full-term neonates were studied. Fifty-one of the at-risk full-term neonates with HIE (51/57) had high serum LPO and two of the at-risk full-term neonates without HIE (2/57) (P<0.001). Serum LPO level had 89% sensitivity, 96% specificity, 96% positive predictive value, 90% negative predictive value, 24 positive probability ratio, 0.11 negative probability ratio and 92% diagnostic usefulness.Conclusion:Serum LPO level could be a useful test for early diagnosis of HIE in full-term neonates.Journal of Perinatology advance online publication, 5 April 2012; doi:10.1038/jp.2012.38. |
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Authors:
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J C Barrera-de León; R Cervantes-Munguía; C Vásquez; M A Higareda-Almaraz; A Bravo-Cuellar; L González-López |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-4-05 |
Journal Detail:
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Title: Journal of perinatology : official journal of the California Perinatal Association Volume: - ISSN: 1476-5543 ISO Abbreviation: - Publication Date: 2012 Apr |
Date Detail:
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Created Date: 2012-4-6 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8501884 Medline TA: J Perinatol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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UMAE Hospital de Pediatría CMNO, Instituto Mexicano del Seguro Social, Hospital Materno Infantil Esperanza López Mateos, Secretaria de Salud Jalisco, Guadalajara, Mexico. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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