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Usefulness of serum lipid peroxide as a diagnostic test for hypoxic ischemic encephalopathy in the full-term neonate.
MedLine Citation:
PMID:  22481245     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Objective:To evaluate the usefulness of serum lipid peroxide (LPO) for hypoxic ischemic encephalopathy (HIE) in full-term neonates.Study Design:Diagnostic test evaluation forming three groups: (1) healthy full-term neonates (n=59), (2) at-risk full-term neonates without HIE (n=57) and (3) at-risk full-term neonates with HIE (n=57). HIE diagnosis was made using the Finer clinical classification at 48 h after birth. Serum LPO was taken at 4 h after birth and determined by spectrophotometry.Result:One hundred seventy-three full-term neonates were studied. Fifty-one of the at-risk full-term neonates with HIE (51/57) had high serum LPO and two of the at-risk full-term neonates without HIE (2/57) (P<0.001). Serum LPO level had 89% sensitivity, 96% specificity, 96% positive predictive value, 90% negative predictive value, 24 positive probability ratio, 0.11 negative probability ratio and 92% diagnostic usefulness.Conclusion:Serum LPO level could be a useful test for early diagnosis of HIE in full-term neonates.Journal of Perinatology advance online publication, 5 April 2012; doi:10.1038/jp.2012.38.
Authors:
J C Barrera-de León; R Cervantes-Munguía; C Vásquez; M A Higareda-Almaraz; A Bravo-Cuellar; L González-López
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-4-05
Journal Detail:
Title:  Journal of perinatology : official journal of the California Perinatal Association     Volume:  -     ISSN:  1476-5543     ISO Abbreviation:  -     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-4-6     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8501884     Medline TA:  J Perinatol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
UMAE Hospital de Pediatría CMNO, Instituto Mexicano del Seguro Social, Hospital Materno Infantil Esperanza López Mateos, Secretaria de Salud Jalisco, Guadalajara, Mexico.
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