| Usefulness of serum high-density lipoprotein cholesterol level as an independent predictor of one-year mortality after percutaneous coronary interventions. | |
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MedLine Citation:
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PMID: 19327413 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Low levels of high-density lipoprotein (HDL) cholesterol are a marker of coronary artery disease progression and are associated with cardiovascular events. However, whether low HDL cholesterol is a useful prognostic indicator after percutaneous coronary intervention (PCI) is not known. In a sample of 4,088 patients who underwent PCI we evaluated 1-year mortality and repeat revascularization as a function of baseline HDL levels classified into approximate quartiles of very low (<35 mg/dl), low (35 to 40 mg/dl), medium (41 to 47 mg/dl) and high (48 to 120 mg/dl) HDL cholesterol. Decreasing levels of HDL cholesterol were associated with younger age, male gender, smoking, diabetes mellitus, and a history of bypass surgery (p <0.0001 for all). One-year mortality and coronary revascularization were significantly higher in the very low HDL cholesterol group compared with the other groups (very low HDL cholesterol 6.5% and 25.4%, respectively; low HDL cholesterol 3.1% and 20.8%; medium HDL cholesterol 4.3% and 22.7%; high HDL cholesterol 3.1% and 20.6%, p = 0.0001 and p = 0.007). One-year mortality was significantly higher in men with an HDL cholesterol level <33 mg/dL and in women with an HDL cholesterol level <38 mg/dL. In multivariable analysis, very low HDL was associated with nearly twofold the risk of death after adjusting for other independent predictors of outcome. In conclusion, in patients with coronary artery disease undergoing PCI, a baseline HDL cholesterol level <35 mg/dl is an important prognostic indicator. Baseline HDL cholesterol levels <33 mg/dl for men and <38 mg/dl were associated with higher one-year mortality after PCI. |
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Authors:
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Ziyad B Ghazzal; Saurabh S Dhawan; Abdul Sheikh; John S Douglas; Emir Veledar; Kreton Mavromatis; F Khan Pohlel; Viola Vaccarino |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: The American journal of cardiology Volume: 103 ISSN: 1879-1913 ISO Abbreviation: Am. J. Cardiol. Publication Date: 2009 Apr |
Date Detail:
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Created Date: 2009-03-30 Completed Date: 2009-04-14 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0207277 Medline TA: Am J Cardiol Country: United States |
Other Details:
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Languages: eng Pagination: 902-6 Citation Subset: AIM; IM |
Affiliation:
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Division of Cardiology, Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA. ziyad.ghazzal@emoryhealthcare.org |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Angioplasty, Transluminal, Percutaneous Coronary / methods* Biological Markers / blood Cholesterol, HDL / blood* Female Follow-Up Studies Georgia / epidemiology Humans Male Middle Aged Myocardial Ischemia / blood, mortality*, therapy Prognosis Prospective Studies Recurrence Risk Factors Sex Factors Survival Rate / trends |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Cholesterol, HDL |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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